Sample:
Lane 1: Mouse Plasma
Lane 2: Recombinant human Haptoglobin protein(bs-43006P)at 50ng
Primary: Anti-Haptoglobin (bs-1808R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 27/43kDa
Observed band size: 27/43kDa
- ￥1180 - 2800
- Bioss
- bs-1808R
- 2025年10月24日
- 产品信息以Bioss网站为准
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产品信息以Bioss网站为准
- 规格：
50ul/100ul/200ul
| 规格： | 50ul | 产品价格： | ￥1180.0 |
|---|---|---|---|
| 规格： | 100ul | 产品价格： | ￥1980.0 |
| 规格： | 200ul | 产品价格： | ￥2800.0 |
| 产品编号 | bs-1808R |
| 英文名称 | Haptoglobin Rabbit pAb |
| 中文名称 | 结合珠蛋白/触珠蛋白抗体 |
| 英文别名 | haptoglobin; Bp; Haptoglobin alpha chain; Haptoglobin alpha(1S) beta; Haptoglobin alpha(2FS) beta; Haptoglobin beta chain; Haptoglobin, alpha polypeptide; Haptoglobin, beta polypeptide; HP; Hp2 alpha; HP2 ALPHA2; HPA1S; HPT; MGC111141; HPT_HUMAN. |
| 产品应用 | WB=1:500-2000 Not yet tested in other applications. |
| 交叉反应 | Human, Mouse |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human Haptoglobin beta chain |
| 亚型 | IgG |
| 性状 | Liquid |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 理论分子量 | 27/43 kDa |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 亚基 | Tetramer of two alpha and two beta chains; disufide-linked. The Hemoglobin/haptoglobin complex is composed of a haptoglobin dimer bound to two hemoglobin alpha-beta dimers. Interacts with CD163. |
| 亚细胞定位 | Secreted. |
| 组织特异性 | Expressed by the liver and secreted in plasma. |
| 相似性 | Belongs to the peptidase S1 family. Contains 1 peptidase S1 domain. Contains 2 Sushi (CCP/SCR) domains. |
| 功能 | As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an Antimicrobial; Antioxidant, has antibacterial activity and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidely cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway. Uncleaved haptoglogin, also known as zonulin, plays a role in intestinal permeability, allowing intercellular tight junction disassembly, and controlling the equilibrium between tolerance and immunity to non-self antigens. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | This gene encodes a preproprotein, which is processed to yield both alpha and beta chains, which subsequently combine as a tetramer to produce haptoglobin. Haptoglobin functions to bind free plasma hemoglobin, which allows degradative enzymes to gain access to the hemoglobin, while at the same time preventing loss of iron through the kidneys and protecting the kidneys from damage by hemoglobin. Mutations in this gene and/or its regulatory regions cause ahaptoglobinemia or hypohaptoglobinemia. This gene has also been linked to diabetic nephropathy, the incidence of coronary artery disease in type 1 diabetes, Crohn's disease, inflammatory disease behavior, primary sclerosing cholangitis, susceptibility to idiopathic Parkinson's disease, and a reduced incidence of Plasmodium falciparum malaria. A similar duplicated gene is located next to this gene on chromosome 16. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| 应用 | 推荐稀释比例 |
| {WB} | {1:500-2000} |
Sample:
Liver (Mouse) Lysate at 40 ug
Primary: Anti-Haptoglobin (bs-1808R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 27/43 kD
Observed band size: 27 kD
Liver (Mouse) Lysate at 40 ug
Primary: Anti-Haptoglobin (bs-1808R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 27/43 kD
Observed band size: 27 kD
Sample:
Hela(Human) Cell Lysate at 40 ug
Primary: Anti-Haptoglobin (bs-1808R) at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 27/43 kD
Observed band size: 45 kD
Hela(Human) Cell Lysate at 40 ug
Primary: Anti-Haptoglobin (bs-1808R) at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 27/43 kD
Observed band size: 45 kD
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文献和实验该产品被引用文献
[IF={{ 7.8 }}] {Lin Liu. et al. Potential Applications of Dual Haptoglobin Expression in the Reclassification and Treatment of Hepatocellular Carcinoma. TRANSL RES. 2024 May;:} {WB} {Human}
[IF={{ 6.2 }}] {Sprenger-Svačina Alina. et al. Antibiotics-Induced Intestinal Immunomodulation Attenuates Experimental Autoimmune Neuritis (EAN). J NEUROIMMUNE PHARM. 2024 Dec;19(1):1-13} {IF} {Rat}
[IF={{ 2.5 }}] {Yalçın Buğdaycı Azimet. et al. Investigation of the relationship between inflammation and microbiota in the intestinal tissue of female and male rats fed with fructose: Modulatory role of metformin. DARU. 2024 Jun;:1-21} {IHC} {Rat}
[IF={{ 2.31 }}] {Kälsch, Julia, et al. "Bathing in carbon dioxide-enriched water alters protein expression in keratinocytes of skin tissue in rats." International Journal of Biometeorology (2016): 1-8.} {IHC} {="Rat"}
[IF={{ 2.088 }}] {Wang G et al. PPAR-γ Promotes Hematoma Clearance through Haptoglobin-Hemoglobin-CD163 in a Rat Model of Intracerebral Hemorrhage. Behavioural Neurology, 2018, 1–7.} {WB} {Rat}
相关实验
= NAL), appears to form upon oxidative cyclization of the nonfluorescent 2:1 lysine-HNE Michael adduct-Schiff base cross-link (Scheme 1). Polyclonal antibody (PAb) to the NAL-HNE fluorophore was raised in rabbit and found to be highly specific
GE Healthcare Benzamidine Sepharose™ 6B is p-aminobenzamidine covalently attached to Sepharose 6B by the epoxy coupling method. p-Aminobenzamidine (PAB), is a synthetic inhibitor of trypsin-like serine protease. Trypsin and trypsin
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Haptoglobin Rabbit pAb(bs-1808R)-50ul/100ul/200ul
￥1180 - 2800
