Sample:
Lung (Mouse) Lysate at 40 ug
Heart (Rat) Lysate at 40 ug
Primary: Anti- Mast Cell Chymase (bs-2353R) at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 25 kD
Observed band size: 23 kD
- ￥1180 - 2800
- Bioss
- bs-2353R
- 2025年10月24日
- 产品信息以Bioss网站为准
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- 规格：
50ul/100ul/200ul
| 规格： | 50ul | 产品价格： | ￥1180.0 |
|---|---|---|---|
| 规格： | 100ul | 产品价格： | ￥1980.0 |
| 规格： | 200ul | 产品价格： | ￥2800.0 |
| 产品编号 | bs-2353R |
| 英文名称 | CMA1 Rabbit pAb |
| 中文名称 | 肥大细胞类糜蛋白酶1抗体 |
| 英文别名 | CMA1_HUMAN; Chymase; EC:3.4.21.39; CYH; CYM; Mast Cell Chymase; alpha-chymase; Mast cell protease I; |
| 中文别名 | |
| 产品应用 | WB=1:500-2000 Not yet tested in other applications. |
| 交叉反应 | Human, Mouse, Rat (Sheep, GuineaPig) |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human CMA1 |
| 亚型 | IgG |
| 性状 | Liquid |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 理论分子量 | 25 kDa |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Cardiovascular > Atherosclerosis > Vascular Inflammation > Inflammatory mediators Cardiovascular > Blood Immunology > Innate Immunity > Macrophage / Inflamm. Signal Transduction > Cytoskeleton / ECM > Extracellular Matrix > ECM Enzymes > Other Enzymes |
| 亚细胞定位 | Secreted. Cytoplasmic granule. Note=Mast cell granules. |
| 组织特异性 | Mast cells in lung, heart, skin and placenta. Expressed in both normal skin and in urticaria pigmentosa lesions. |
| 相似性 | Belongs to the peptidase S1 family. Granzyme subfamily.
Contains 1 peptidase S1 domain. |
| 功能 | Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Mast cells contain a number of preformed chemicals mediators such as histamine, chymase, carboxypeptidase and proteolytic tryptase. Human Mast Cell Chymase is considered to be an important marker of mast cells as well as an important mediator of inflammation. |
| 应用 | 推荐稀释比例 |
| {WB} | {1:500-2000} |
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文献和实验该产品被引用文献
[IF={{ 3.73 }}] {Wang H, Jessup JA, Zhao Z, Da Silva J, Lin M, et al. (2013) Characterization of the Cardiac Renin Angiotensin System in Oophorectomized and Estrogen-Replete mRen2.Lewis Rats. PLoS ONE 8(10):e76992.} {WB} {="Rat"}
[IF={{ 3.73 }}] {Zheng J, Wei C-C, Hase N, Shi K, Killingsworth CR, et al. (2014) Chymase Mediates Injury and Mitochondrial Damage in Cardiomyocytes during Acute Ischemia/Reperfusion in the Dog. PLoS ONE 9(4): e94732.} {IHC} {="Dog"}
[IF={{ 3.23 }}] {Sansoè, Giovanni, et al. "Role of Chymase in the Development of Liver Cirrhosis and Its Complications: Experimental and Human Data." PLOS ONE11.9 (2016): e0162644.} {IHC} {="Human, Rat"}
[IF={{ 2.28 }}] {Zhao, Zhuo, et al. "GPR30 Decreases Cardiac Chymase/Angiotensin II by Inhibiting Local Mast Cell Number." Biochemical and Biophysical Research Communications (2015).} {WB,IHC} {="Rat"}
[IF={{ 16.6 }}] {Renga Giorgia. et al. Bridging of host-microbiota tryptophan partitioning by the serotonin pathway in fungal pneumonia. NAT COMMUN. 2023 Sep;14(1):1-21} {IF} {Mouse}
相关实验
= NAL), appears to form upon oxidative cyclization of the nonfluorescent 2:1 lysine-HNE Michael adduct-Schiff base cross-link (Scheme 1). Polyclonal antibody (PAb) to the NAL-HNE fluorophore was raised in rabbit and found to be highly specific
GE Healthcare Benzamidine Sepharose™ 6B is p-aminobenzamidine covalently attached to Sepharose 6B by the epoxy coupling method. p-Aminobenzamidine (PAB), is a synthetic inhibitor of trypsin-like serine protease. Trypsin and trypsin
Nucleic Acid Programmable Protein Arrays: Versatile Tools for Array‐Based Functional Protein Studies
.g., Sigma) 50 mg/ml bis‐sulfosuccinimdylsuberate (BS3 ;Pierce, cat. no. PI 21580) in dimethylsulfoxide (DMSO) 5 mg/ml
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CMA1 Rabbit pAb(bs-2353R)-50ul/100ul/200ul
￥1180 - 2800
