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| 规格： | 50ul | 产品价格： | ￥1180.0 |
|---|---|---|---|
| 规格： | 100ul | 产品价格： | ￥1980.0 |
| 规格： | 200ul | 产品价格： | ￥2800.0 |
| 产品编号 | bs-9505R |
| 英文名称 | alpha 2 Macroglobulin Rabbit pAb |
| 中文名称 | α2巨球蛋白(α-2M)抗体 |
| 英文别名 | A2M; α-2M; A2MG_HUMAN; alpha 2 M; alpha 2M; alpha-2-M; alpha-2-macroglobulin; alpha-2 Macroglobulin; alpha 2-Macroglobulin; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5; CPAMD5; DKFZp779B086; FWP007; S863 7. |
| 产品应用 | WB=1:500-2000 Not yet tested in other applications. |
| 交叉反应 | Human (Mouse, Rat) |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human alpha 2 Macroglobulin |
| 亚型 | IgG |
| 性状 | Liquid |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 理论分子量 | 160 kDa |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Cardiovascular > Blood > Serum Proteins Cell Biology > Proteolysis / Ubiquitin > Protease inhibitors > Other protease inhibitors |
| 亚基 | Homotetramer; disulfide-linked. |
| 亚细胞定位 | Secreted |
| 组织特异性 | Secreted in plasma |
| 相似性 | Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family. |
| 功能 | Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Alpha-2-macroglobulin is a protease inhibitor and cytokine transporter. It inhibits many proteases, including trypsin, thrombin and collagenase. A2M is implicated in Alzheimer disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. [provided by RefSeq, Jul 2008]. |
| 应用 | 推荐稀释比例 |
| {WB} | {1:500-2000} |
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文献和实验[IF={{ 3.7 }}] {Liu, Ranran, et al. "Uncovering the embryonic development-related proteome and metabolome signatures in breast muscle and intramuscular fat of fast-and slow-growing chickens." BMC Genomics 18.1 (2017): 816.} {WB} {="Chicken"}
[IF={{ 1.56 }}] {Hu, Hai Xia, et al. "Anti-inflammatory effects of Gualou Guizhi decoction in transient focal cerebral ischemic brains. Corrigendum in/mmr/12/3/3998." Molecular medicine reports 12.1 (2015): 1321-1327.} {IHC} {="Rat"}
[IF={{ 1.243 }}] {Shu et al. Differentially expressed serum proteins associated with calcium regulation and hypocalcemia in dairy cows. (2017) Asian-Australas.J.Anim.Sc. 30:893-901} {WB} {Bovine}
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