- ￥1180 - 2800
- Bioss
- bs-7022R
- 2025年10月16日
- 产品信息以Bioss网站为准
企业认证
相关产品推荐更多 >
phospho-ERK1/ERK2(phospho-T183/Y185) Rabbit pAb, PE-Cy5 conjugated(bs-1522R-PE-Cy5)-100ul
￥2980HER2 Rabbit pAb, PE-Cy5.5 conjugated(bs-2048R-PE-Cy5.5)-100ul
￥2980M Cadherin Rabbit pAb, AP conjugated(bs-6678R-AP)-100ul
￥2980TAZ Rabbit pAb, APC-Cy5.5 conjugated(bs-12367R-APC-Cy5.5)-100ul
￥2980
SERPIN A11 Rabbit pAb(bs-20816R)-50ul/100ul/200ul
￥1180
万千商家帮你免费找货
0 人在求购买到急需产品
- 详细信息
- 文献和实验
- 技术资料
- 应用范围：
产品信息以Bioss网站为准
- 规格：
50ul/100ul/200ul
| 规格： | 50ul | 产品价格： | ￥1180.0 |
|---|---|---|---|
| 规格： | 100ul | 产品价格： | ￥1980.0 |
| 规格： | 200ul | 产品价格： | ￥2800.0 |
| 产品编号 | bs-7022R |
| 英文名称 | IFNAR2 Rabbit pAb |
| 中文名称 | 干扰素α受体2抗体 |
| 英文别名 | IFN alpha REC; IFN-alpha binding protein; IFN-alpha/beta receptor 2; IFN-R-2; IFNABR; IFNAR2; IFNARB; IFNR; INAR2_MOUSE; Interferon alpha binding protein; Interferon alpha/beta receptor 2; Interferon alpha/beta receptor beta chain; Type I interferon receptor 2; Type I interferon receptor. |
| 产品应用 | WB=1:500-2000, IHC-P=1:50-200, IHC-F=1:50-200, ICC/IF=1:50-200, IF=1:50-200, ELISA=1:1000-5000 Not yet tested in other applications. |
| 交叉反应 | Human, Rat, Mouse |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from mouse IFNAR2 |
| 亚型 | IgG |
| 性状 | Liquid |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 理论分子量 | 54 kDa |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Cancer > Tumor immunology > Cytokines > Interferons Epigenetics and Nuclear Signaling > Nuclear Signaling Pathways > STATs Immunology > Innate Immunity > Cytokines > Interferons Microbiology > Organism > Virus > RNA Virus > ssRNA positive strand virus > SARS Coronavirus Signal Transduction > Signaling Pathway > Nuclear Signaling > STATs |
| 亚基 | Heterodimer with IFNAR1; in presence of interferon alpha and/or beta ligands forms the type I interferon receptor. Isoform 1 interacts with the transcriptional factors STAT1 and STAT2. Interacts with JAK1. |
| 亚细胞定位 | Isoform 1: Membrane; Single-pass type I membrane protein. Isoform 2: Secreted (Probable). Isoform 3: Secreted (Probable). |
| 组织特异性 | Widely expressed. Detected in liver, testis, kidney, salivary gland, thymus, brain, lung and placenta. Isoform 1, isoform 2 and isoform 3 are expressed in brain. |
| 翻译后修饰 | Phosphorylated on tyrosine residues upon interferon binding. Phosphorylation at Tyr-335 or Tyr-510 are sufficient to mediate interferon dependent activation of STAT1, STAT2 and STAT3 leading to antiproliferative effects on many different cell types.
Glycosylated. |
| 相似性 | Belongs to the type II cytokine receptor family. |
| 功能 | Associates with IFNAR1 to form the type I interferon receptor. Receptor for interferons alpha and beta. Involved in IFN-mediated STAT1, STAT2 and STAT3 activation. Isoform 1 and isoform 2 are directly involved in signal transduction due to their association with the TYR kinase, JAK1. Isoform 2 and 3 may be potent inhibitors of type I IFN receptor activity. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. Multiple transcript variants encoding at least two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| 应用 | 推荐稀释比例 |
| {WB} | {1:500-2000} |
| {IHC-P} | {1:50-200} |
| {IHC-F} | {1:50-200} |
| {ICC/IF} | {1:50-200} |
| {IF} | {1:50-200} |
| {ELISA} | {1:1000-5000} |
风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
文献和实验[IF={{ 2.66 }}] {Lopušná, Katarína, et al. "Murine gammaherpesvirus targets type I IFN receptor but not type III IFN receptor early in infection." Cytokine 83 (2016): 158-170.} {WB} {="Mouse"}
[IF={{ 1.5 }}] {Sakumoto R et al. Pregnancy-associated changes of Peroxisome Proliferator-Activated Receptor Delta (PPARD) and Cytochrome P450 Family 21 Subfamily A Member 2 (CYP21A2) expression in the bovine corpus luteum. J Reprod Dev. 2020 Feb 7.} {IHC} {Bovine}
技术资料暂无技术资料 索取技术资料
