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- bs-9622R
- 2026年10月13日
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| 规格： | 50ul | 产品价格： | ￥1180.0 |
|---|---|---|---|
| 规格： | 100ul | 产品价格： | ￥1980.0 |
| 规格： | 200ul | 产品价格： | ￥2800.0 |
| 产品编号 | bs-9622R |
| 英文名称 | Tropomyosin Rabbit pAb |
| 中文名称 | 原肌球蛋白1抗体 |
| 英文别名 | Tropomyosin 1(alpha); alpha tropomyosin; alpha-tropomyosin; C15orf13; cardiomyopathy, hypertrophic 3; CMD1Y; CMH3; HTM alpha; sarcomeric tropomyosin kappa; TMSA; TPM1; TPM1_HUMAN; Tropomyosin 1; Tropomyosin1; Tropomyosin alpha 1 chain; Tropomyosin alpha-1 chain; Tropomyosin-1; Tropomyosin α; Tropomyosin-α; Tropomyosinα. |
| 产品应用 | IHC-P=1:100-500, IHC-F=1:100-500, IF=1:100-500 Not yet tested in other applications. |
| 交叉反应 | Human (Mouse, Rat, Dog, Zebrafish, Sheep) |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human Tropomyosin |
| 亚型 | IgG |
| 性状 | Liquid |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 理论分子量 | 33 kDa |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Cardiovascular > Heart > Hypertrophy Signal Transduction > Cytoskeleton / ECM > Cytoskeleton > Microfilaments > Actin etc > Tropomyosin |
| 亚基 | Heterodimer of an alpha and a beta chain (By similarity). Interacts with HRG (via the HRR domain); the interaction contributes to the antiangiogenic properties of the histidine/proline-rich region (HRR) of HRG. |
| 亚细胞定位 | Cytoplasm, cytoskeleton. |
| 组织特异性 | Detected in primary breast cancer tissues but undetectable in normal breast tissues in Sudanese patients. Isoform 1 is expressed in adult and fetal skeletal muscle and cardiac tissues, with higher expression levels in the cardiac tissues. Isoform 10 is expressed in adult and fetal cardiac tissues, but not in skeletal muscle. |
| 翻译后修饰 | Phosphorylated at Ser-283 by DAPK1 in response to oxidative stress and this phosphorylation enhances stress fiber formation in endothelial cells. |
| 相似性 | Belongs to the tropomyosin family. _x000D_ |
| 功能 | Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. |
| 应用 | 推荐稀释比例 |
| {IHC-P} | {1:100-500} |
| {IHC-F} | {1:100-500} |
| {IF} | {1:100-500} |
Paraformaldehyde-fixed, paraffin embedded (human myocardial); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (Tropomyosin) Polyclonal Antibody, Unconjugated (bs-9622R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
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文献和实验该产品被引用文献
[IF=5.6] Rong Tang. et al. Single-cell transcriptomics uncover hub genes and cell–cell crosstalk in patients with hypertensive nephropathy. INT IMMUNOPHARMACOL. 2023 Dec;125:111104 IHC Human,Mouse
[IF=5.1] Xiaochen Wang. et al. Obesity-aggravated erythrocyte injury in ischaemia-reperfusion: Interlinked oxidative stress, metabolic reprogramming, and cytoskeletal destabilisation. LIFE SCI. 2025 Nov;380:123975 WB Mouse
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TPM1 | Tropomyosin-1 Rabbit pAb(bs-9622R)-50ul/100ul/200ul
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