MBTPS1 | S1P/SKI1 Rabbit pAb(bs-19355R)-50ul/100ul/200ul产品图
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MBTPS1 | S1P/SKI1 Rabbit pAb(b

s-19355R)-50ul/100ul/200ul
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  • ￥1180 - 2800
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  • bs-19355R
  • 2026年10月13日
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    北京博奥森生物技术有限公司
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      50ul/100ul/200ul

    规格：50ul产品价格：￥1180.0
    规格：100ul产品价格：￥1980.0
    规格：200ul产品价格：￥2800.0
    产品编号bs-19355R
    英文名称S1P/Subtilisin isozyme 1 Rabbit pAb
    中文名称枯草杆菌蛋白酶同工酶1抗体
    英文别名kexin isozyme 1; KIAA0091; MBTP1_HUMAN; MBTPS1; membrane bound transcription factor peptidase, site 1; MGC138711; MGC138712; PCSK8; S1P; S1P endopeptidase; Site 1 protease; SKI 1; SKI1; Subtilisin isozyme 1; Subtilisin/kexin isozyme 1.
    产品应用WB=1:500-2000

    Not yet tested in other applications.
    Optimal working dilutions must be determined by the end user.

    交叉反应Mouse (Human, Rat, Chicken, Rabbit)
    抗体来源Rabbit
    免疫原KLH conjugated synthetic peptide derived from human S1P/Subtilisin isozyme 1
    亚型IgG
    性状Liquid
    纯化方法affinity purified by Protein A
    克隆类型Polyclonal
    理论分子量96 kDa
    浓度1mg/ml
    储存液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
    研究领域

    Cell Biology > Proteolysis / Ubiquitin > Proteolytic enzymes > Other proteases

    Epigenetics and Nuclear Signaling > Transcription > Other factors

    Metabolism > Pathways and Processes > Metabolic signaling pathways > Lipid and lipoprotein metabolism > Lipid metabolism

    Signal Transduction > Metabolism > Lipid metabolism

    亚基Processes precursors containing basic and hydrophobic/aliphatic residues at P4 and P2, respectively, with a relatively relaxed acceptance of amino acids at P1 and P3.
    亚细胞定位Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein.
    组织特异性Widely expressed.
    翻译后修饰The 148 kDa zymogen is processed progressively into two membrane-bound 120 and 106 kDa forms in the endoplasmic reticulum, and late into a secreted 98 kDa form. The propeptide is autocatalytically removed through an intramolecular cleavage after Leu-186. Further cleavage generates 14, 10, and 8 kDa intermediates.
    相似性Belongs to the peptidase S8 family.
    Contains 1 peptidase S8 domain._x000D_
    功能Serine protease that catalyzes the first step in the proteolytic activation of the sterol regulatory element-binding proteins (SREBPs). Other known substrates are BDNF, GNPTAB and ATF6. Cleaves after hydrophobic or small residues, provided that Arg or Lys is in position P4. Cleaves known substrates after Arg-Ser-Val-Leu (SERBP-2), Arg-His-Leu-Leu (ATF6), Arg-Gly-Leu-Thr (BDNF) and its own propeptide after Arg-Arg-Leu-Leu. Mediates the protein cleavage of GNPTAB into subunit alpha and beta, thereby participating in biogenesis of lysosomes.
    保存条件Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
    注意事项This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
    背景资料This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an initial autocatalytic processing event in the ER to generate a heterodimer which exits the ER and sorts to the cis/medial-Golgi where a second autocatalytic event takes place and the catalytic activity is acquired. It encodes a type 1 membrane bound protease which is ubiquitously expressed and regulates cholesterol or lipid homeostasis via cleavage of substrates at non-basic residues. Mutations in this gene may be associated with lysosomal dysfunction. [provided by RefSeq, Feb 2014]

     

    应用推荐稀释比例
    {WB}{1:500-2000}

     

    产品细节图片1
    Sample:
    _x000D_ Adrenal gland (Mouse) Lysate at 40 ug
    _x000D_ Primary: Anti-S1P/Subtilisin isozyme 1  (bs-19355R) at 1/500 dilution
    _x000D_ Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
    _x000D_ Predicted band size: 96 kD
    _x000D_ Observed band size: 126 kD

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    [IF=4.162] Dianna Liu. et al. Network Pharmacology and Experimental Verification to Explore the Potential Mechanism of Yin-Huo-Tang for Lung Adenocarcinoma Recurrence. Drug Des Dev Ther. 2022; 16: 375–395 WB Mouse

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    MBTPS1 | S1P/SKI1 Rabbit pAb(bs-19355R)-50ul/100ul/200ul
    ￥1180 - 2800