PTGER2 | EP2 Rabbit pAb(bs-4196R)-50ul/100ul/200ul产品图
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PTGER2 | EP2 Rabbit pAb(bs-419

6R)-50ul/100ul/200ul
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  • ¥1180 - 2800
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  • bs-4196R
  • 2026年10月13日
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      50ul/100ul/200ul

    规格:50ul产品价格:¥1180.0
    规格:100ul产品价格:¥1980.0
    规格:200ul产品价格:¥2800.0
    产品编号bs-4196R
    英文名称PTGER2 Rabbit pAb
    中文名称前列腺素E2受体2抗体
    英文别名EP 2; EP2; Prostaglandin E Receptor EP2; Human prostaglandin E2 receptor; PE2R2_HUMAN; PGE receptor EP2 subtype; PGE2 receptor EP2 subtype; Prostaglandin E receptor 2 EP2 subtype; Prostaglandin E receptor 2 subtype EP2 53kDa; Prostaglandin E receptor 2 subtype EP2; Prostaglandin E2 receptor; Prostaglandin E2 receptor EP2 subtype; Prostanoid EP2 receptor; PTGER 2; PTGER2.
    产品应用WB=1:500-2000

    Not yet tested in other applications.
    Optimal working dilutions must be determined by the end user.

    交叉反应Human, Mouse, Rat (Dog, Pig, Cow, Rabbit, Sheep)
    抗体来源Rabbit
    免疫原KLH conjugated synthetic peptide derived from human Prostaglandin E Receptor EP2
    亚型IgG
    性状Liquid
    纯化方法affinity purified by Protein A
    克隆类型Polyclonal
    理论分子量40 kDa
    浓度1mg/ml
    储存液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
    研究领域

    Signal Transduction > Metabolism > Lipid metabolism

    Signal Transduction > Signaling Pathway > Lipid Signaling > Prostaglandins

    亚细胞定位Cell membrane; Multi-pass membrane protein.
    组织特异性Placenta and lung.
    相似性Belongs to the G-protein coupled receptor 1 family.
    功能Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. The subsequent raise in intracellular cAMP is responsible for the relaxing effect of this receptor on smooth muscle.
    保存条件Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
    注意事项This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
    背景资料Prostaglandins are produced by the metabolism of arachidonic acid. Prostaglandin E2 is one of the five physiologically significant prostanoids known. Its wide spectrum of physiologic and pharmacologic effects in various tissues is mediated through binding to the Prostaglandin E2 receptors (EP1, EP2, EP3 & EP4). These include effects on the immune, endocrine, cardiovascular, renal and reproductive systems as well as smooth muscle. It is also one of the most abundant of the prostanoid family in the brain where it plays an important role in many neural functions, particularly in newborn babies, and as a mediator of inflammation. Prostaglandin E2 signals through a family of G-protein coupled receptors known as EP receptors. There are 4 subtypes of EP receptors, known as EP1, EP2, EP3 and EP4. EP2 receptors are 358 amino acid proteins with a short third intracellular loop. EP2 receptors stimulate adenylyl cyclase by their coupling to Gs and do not undergo Prostaglandin E2 induced internalization. The EP2 receptors is involved with the contration and relaxation of smooth muscle tissue. These receptors are mainly localized in lung and placental tissues and in smooth muscle.

     

    应用推荐稀释比例
    {WB}{1:500-2000}

     

    产品细节图片1
    Sample:
    _x000D_ Lane 1: Mouse Spleen tissue lysates
    _x000D_ Lane 2: Mouse Urinary bladder tissue lysates
    _x000D_ Lane 3: Mouse Placenta tissue lysates
    _x000D_ Lane 4: Rat Urinary bladder tissue lysates
    _x000D_ Lane 5: Rat Placenta tissue lysates
    _x000D_ Lane 6: Human MCF-7 cell lysates
    _x000D_ Lane 7: Human JAR cell lysates
    _x000D_ Lane 8: Human HL60 cell lysates
    _x000D_ Primary: Anti-PTGER2 (bs-4196R) at 1/1000 dilution
    _x000D_ Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
    _x000D_ Predicted band size: 40 kDa
    _x000D_ Observed band size: 48 kDa

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    PTGER2 | EP2 Rabbit pAb(bs-4196R)-50ul/100ul/200ul
    ¥1180 - 2800