SIRT3 Rabbit pAb(bs-6105R)-50ul/100ul/200ul
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SIRT3 Rabbit pAb(bs-6105R)-50u

l/100ul/200ul
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  • ￥1180 - 2800
  • Bioss已认证
  • bs-6105R
  • 2025年10月24日
  • 产品信息以Bioss网站为准
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北京博奥森生物技术有限公司
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      50ul/100ul/200ul

    规格：50ul产品价格：￥1180.0
    规格：100ul产品价格：￥1980.0
    规格：200ul产品价格：￥2800.0
    产品编号bs-6105R
    英文名称SIRT3 Rabbit pAb
    中文名称线粒体乙酰化酶3抗体
    英文别名hSIRT3; hSIRT 3; hSIRT3; Mitochondrial nicotinamide adenine dinucleotide dependent deacetylase; NAD dependent deacetylase sirtuin 3 mitochondrial; NAD-dependent deacetylase sirtuin-3, mitochondrial; Silent mating type information regulation 2 S.cerevisiae homolog 3; Sir 2 like 3; SIR 2 like protein 3; SIR 3; SIR2 L3; Sir2 like 3; SIR2 like protein 3; SIR2-like protein 3; SIR2L3; SIRT 3; SIRT3_HUMAN; Sirtuin 3; Sirtuin silent mating type information regulation 2 homolog 3(S. cerevisiae); Sirtuin type 3; Sirtuin3.
    产品应用IHC-P=1:100-500, IHC-F=1:100-500, IF=1:100-500

    Not yet tested in other applications.
    Optimal working dilutions must be determined by the end user.

    交叉反应Human, Rat, heart, heart, heart, heart, stomach, stomach, stomach, stomach, heart, heart, heart
    抗体来源Rabbit
    免疫原KLH conjugated synthetic peptide derived from human SIRT3
    亚型IgG
    性状Liquid
    纯化方法affinity purified by Protein A
    克隆类型Polyclonal
    理论分子量43 kDa
    浓度1mg/ml
    储存液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
    研究领域

    Cancer > Oncoproteins/suppressors > Tumor suppressors

    Cardiovascular > Heart > Cardiac metabolism

    Cell Biology > Cell Cycle > Cell Division > Other cell division antibodies

    Epigenetics and Nuclear Signaling > Chromatin Modifying Enzymes > Acetylation

    Epigenetics and Nuclear Signaling > Chromatin Modifying Enzymes > Acetylation > HDACs > Class III / Sir2 class

    Metabolism > Types of disease > Obesity

    亚基Interacts with NDUFA9, ACSS1, IDH2 and GDH.
    亚细胞定位Mitochondrion matrix.
    组织特异性Widely expressed.
    翻译后修饰Processed by mitochondrial processing peptidase (MPP) to give a 28 kDa product. Such processing is probably essential for its enzymatic activity.
    相似性Belongs to the sirtuin family. Contains 1 deacetylase sirtuin-type domain.
    功能NAD-dependent protein deacetylase. Activates mitochondrial target proteins, including ACSS1, IDH2 and GDH by deacetylating key lysine residues. Contributes to the regulation of the cellular energy metabolism. Important for regulating tissue-specific ATP levels.
    保存条件Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
    注意事项This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
    背景资料SIRT3 encodes a member of the sirtuin family of class III histone deacetylases, homologs to the yeast Sir2 protein. The encoded protein is found exclusively in mitochondria, where it can eliminate reactive oxygen species, inhibit apoptosis, and prevent the formation of cancer cells. SIRT3 has far-reaching effects on nuclear gene expression, cancer, cardiovascular disease, neuroprotection, aging, and metabolic control. [provided by RefSeq, May 2019]

     

    应用推荐稀释比例
    {IHC-P}{1:100-500}
    {IHC-F}{1:100-500}
    {IF}{1:100-500}

     

    SIRT3 Rabbit pAb(bs-6105R)-50u
    P‌‌araformaldehyde-fixed, paraffin embedded (rat stomach); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Incubation with (SIRT3) Polyclonal Antibody, Unconjugated (bs-6105R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
    SIRT3 Rabbit pAb(bs-6105R)-50u
    P‌‌araformaldehyde-fixed, paraffin embedded Rat Liver; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; The section was incubated with SIRT3 Polyclonal Antibody, Unconjugated (bs-6105R) at 1:200 overnight at 4°C, followed by conjugation to the bs-0295G-HRP and DAB (C-0010) staining.
    SIRT3 Rabbit pAb(bs-6105R)-50u
    P‌‌araformaldehyde-fixed, paraffin embedded Human Liver; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; The section was incubated with SIRT3 Polyclonal Antibody, Unconjugated (bs-6105R) at 1:200 overnight at 4°C, followed by conjugation to the bs-0295G-HRP and DAB (C-0010) staining.
    SIRT3 Rabbit pAb(bs-6105R)-50u
    P‌‌araformaldehyde-fixed, paraffin embedded Rat Colon; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; The section was incubated with SIRT3 Polyclonal Antibody, Unconjugated (bs-6105R) at 1:200 overnight at 4°C, followed by conjugation to the bs-0295G-HRP and DAB (C-0010) staining.
    SIRT3 Rabbit pAb(bs-6105R)-50u
    P‌‌araformaldehyde-fixed, paraffin embedded Rat Heart; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; The section was incubated with SIRT3 Polyclonal Antibody, Unconjugated (bs-6105R) at 1:200 overnight at 4°C, followed by conjugation to the bs-0295G-HRP and DAB (C-0010) staining.
    SIRT3 Rabbit pAb(bs-6105R)-50u
    P‌‌araformaldehyde-fixed, paraffin embedded Human Heart; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; The section was incubated with SIRT3 Polyclonal Antibody, Unconjugated (bs-6105R) at 1:200 overnight at 4°C, followed by conjugation to the bs-0295G-HRP and DAB (C-0010) staining.
    SIRT3 Rabbit pAb(bs-6105R)-50u
    P‌‌araformaldehyde-fixed, paraffin embedded Human Colon Cancer; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; The section was incubated with SIRT3 Polyclonal Antibody, Unconjugated (bs-6105R) at 1:200 overnight at 4°C, followed by conjugation to the bs-0295G-HRP and DAB (C-0010) staining.
    SIRT3 Rabbit pAb(bs-6105R)-50u
    P‌‌araformaldehyde-fixed, paraffin embedded Human Kidney; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; The section was incubated with SIRT3 Polyclonal Antibody, Unconjugated (bs-6105R) at 1:200 overnight at 4°C, followed by conjugation to the bs-0295G-HRP and DAB (C-0010) staining.

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    图标文献和实验
    该产品被引用文献

    [IF={{ 6.9 }}] {Lichun Qiao. et al. T-2 toxin induces cardiac fibrosis by causing metabolic disorders and up-regulating Sirt3/FoxO3α/MnSOD signaling pathway-mediated oxidative stress. J ENVIRON SCI-CHINA. 2024 Mar;:} {WB} {Rat}

    [IF={{ 4.546 }}] {Su ShiJie. et al. Kai-Xin-San protects against mitochondrial dysfunction in Alzheimer’s disease through SIRT3/NLRP3 pathway. CHIN MED-UK. 2023 Dec;18(1):1-16} {WB,IF,ICC} {Mouse}

    [IF={{ 4.5 }}] {Jianhui Liu. et al. Melatonin ameliorates PM2.5-induced spermatogenesis disorder by preserving H3K9 methylation and SIRT3. ENVIRON TOXICOL. 2023 Nov;:} {WB} {Mouse}

    [IF={{ 3.448 }}] {Liu L et al. Melatonin ameliorates cerebral ischemia/reperfusion injury through SIRT3 activation. Life Sci. 2019 Nov 4;239:117036.} {IHC} {Mouse}

    [IF={{ 0.496 }}] {Chuanjiang He. et al. MiRNA-494 specifically inhibits SIRT3-mediated microglia activation in sepsis-associated encephalopathy. TRANSL CANCER RES. 2022 Jul; 11(7): 2299–2309} {WB,IHC} {Rat}

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    文献支持
    SIRT3 Rabbit pAb(bs-6105R)-50ul/100ul/200ul
    ￥1180 - 2800