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- bs-1031R
- 2025年10月16日
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50ul/100ul/200ul
| 规格： | 50ul | 产品价格： | ￥1180.0 |
|---|---|---|---|
| 规格： | 100ul | 产品价格： | ￥1980.0 |
| 规格： | 200ul | 产品价格： | ￥2800.0 |
| 产品编号 | bs-1031R |
| 英文名称 | IFITM1 Rabbit pAb |
| 中文名称 | 干扰素诱导跨膜蛋白1抗体 |
| 英文别名 | CD225; CD225 antigen; CD 225; CD-225; IFI17; Interferon induced protein 17; Interferon induced transmembrane protein 1; Interferon inducible protein 9-27; Interferon-induced protein 17; Interferon-induced transmembrane protein 1; Interferon-inducible protein 9-27; Leu 13 antigen; Leu-13 antigen; LEU13; IFM1_HUMAN; Dispanin subfamily A member 2a; DSPA2a. |
| 产品应用 | ELISA=1:5000-10000 Not yet tested in other applications. |
| 交叉反应 | Human (Mouse, Rat) |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human IFITM1 |
| 亚型 | IgG |
| 性状 | Liquid |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 理论分子量 | 11.7 kDa |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Cancer > Oncoproteins/suppressors > Tumor suppressors > p53 pathway Cancer > Tumor biomarkers Immunology > Innate Immunity > Cytokines > Interferons Signal Transduction > Adapters > Transmembrane Stem Cells > Signaling Pathways > TGF beta > Interferon gamma Stem Cells > Signaling Pathways > Wnt > Surface Molecules |
| 亚基 | Interacts with CAV1; this interaction enhances the ability of CAV1 in inhibiting ERK activation. |
| 亚细胞定位 | Cell membrane; Multi-pass membrane protein. |
| 翻译后修饰 | Palmitoylation on membrane-proximal cysteines controls clustering in membrane compartments and antiviral activity against influenza virus. |
| 相似性 | Belongs to the CD225 family. |
| 功能 | IFN-induced antiviral protein that mediate cellular innate immunity to at least three major human pathogens, namely influenza A H1N1 virus, West Nile virus, and dengue virus by inhibiting the early step(s) of replication. Plays a key role in the antiproliferative action of IFN-gamma either by inhibiting the ERK activation or by arresting cell growth in G1 phase in a p53-dependent manner. Implicated in the control of cell growth. Component of a multimeric complex involved in the transduction of antiproliferative and homotypic adhesion signals. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | IFITM1 expression is induced by interferons alpha and gamma and it is thought to play a role in control of cell growth. It is upregulated in several tumor types and may be useful as a tumor biomarker. |
| 应用 | 推荐稀释比例 |
| {ELISA} | {1:5000-10000} |
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文献和实验[IF={{ 2.934 }}] {Jingying Xieet al. Host antiviral protein IFITM2 restricts pseudorabies virus replication. Virus Res . 2020 Oct 2;287:198105.} {WB} {pig}
[IF={{ 2.1 }}] {Huang Lanyi. et al. Scorpion venom heat-resistant peptide alleviates mitochondrial dynamics imbalance induced by PM2.5 exposure by downregulating the PGC-1α/SIRT3 signaling pathway. TOXICOL RES-UK. 2023 Aug;:} {WB} {Mouse}
[IF={{ 1.3 }}] {Yongtao Zhang. et al. The novel role of IFITM1–3 in myogenic differentiation of C2C12 cells. INTRACTABLE RARE DIS. 2023 Aug 18} {WB} {Mouse}
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