Sample:
Skin (Mouse) Lysate at 40 ug
Primary: Anti-GPR109R (bs-10079R) at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 40 kD
Observed band size: 40 kD
- ￥1180 - 2800
- Bioss
- bs-10079R
- 2025年10月24日
- 产品信息以Bioss网站为准
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- 规格：
50ul/100ul/200ul
| 规格： | 50ul | 产品价格： | ￥1180.0 |
|---|---|---|---|
| 规格： | 100ul | 产品价格： | ￥1980.0 |
| 规格： | 200ul | 产品价格： | ￥2800.0 |
| 产品编号 | bs-10079R |
| 英文名称 | GPR109A Rabbit pAb |
| 中文名称 | G蛋白偶联受体109A抗体 |
| 英文别名 | HM74A; G-protein coupled receptor 109A; GPR109A; HM74a; HM74b; NIACR1; Puma-g; PUMAG; Niacr1; Niacin receptor 1; Nicotinic acid receptor; G-protein coupled receptor 109; G-protein coupled receptor HM74; G protein coupled receptor HM74a; G protein coupled receptor Hm74b; Protein PUMA-G; Interferon gamma inducible gene Puma g; Nicotinic acid receptor 1; Nicotinic acid receptor; Puma g; Pumag; rHM74b; HCAR2_HUMAN . |
| 产品应用 | WB=1:500-2000 Not yet tested in other applications. |
| 交叉反应 | Human, Mouse (Rat, Cow, Rabbit) |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human GPR109A/HM74A |
| 亚型 | IgG |
| 性状 | Liquid |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 理论分子量 | 40 kDa |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Cardiovascular > Lipids / Lipoproteins > Lipid Metabolism > Hydrolysis Cell Biology > Apoptosis > Intracellular > p53 Pathway Metabolism > Pathways and Processes > Metabolic signaling pathways > Lipid and lipoprotein metabolism > Hydrolysis Metabolism > Types of disease > Cancer Signal Transduction > Signaling Pathway > G Protein Signaling > GPCR |
| 亚细胞定位 | Cell membrane; Multi-pass membrane protein. |
| 组织特异性 | Expression largely restricted to adipose tissue and spleen. Expressed on mature neutrophils but not on immature neutrophils or eosinophils. |
| 相似性 | Belongs to the G-protein coupled receptor 1 family. |
| 功能 | Acts as a high affinity receptor for both nicotinic acid (also known as niacin) and (D)-beta-hydroxybutyrate and mediates increased adiponectin secretion and decreased lipolysis through G(i)-protein-mediated inhibition of adenylyl cyclase. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet. Mediates nicotinic acid-induced apoptosis in mature neutrophils. Receptor activation by nicotinic acid results in reduced cAMP levels which may affect activity of cAMP-dependent protein kinase A and phosphorylation of target proteins, leading to neutrophil apoptosis. The rank order of potency for the displacement of nicotinic acid binding is 5-methyl pyrazole-3-carboxylic acid = pyridine-3-acetic acid > acifran > 5-methyl nicotinic acid = acipimox >> nicotinuric acid = nicotinamide. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Acts as a high affinity receptor for both nicotinic acid (also known as niacin) and (D)-beta-hydroxybutyrate and mediates increased adiponectin secretion and decreased lipolysis through G(i)-protein-mediated inhibition of adenylyl cyclase. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet. Mediates nicotinic acid-induced apoptosis in mature neutrophils. Receptor activation by nicotinic acid results in reduced cAMP levels which may affect activity of cAMP-dependent protein kinase A and phosphorylation of target proteins, leading to neutrophil apoptosis. |
| 应用 | 推荐稀释比例 |
| {WB} | {1:500-2000} |
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文献和实验该产品被引用文献
[IF={{ 8.74 }}] {Yao Yao. et al. Short-chain fatty acids regulate B cells differentiation via FFAR2 to alleviate rheumatoid arthritis. BRIT J PHARMACOL. 2022 Apr 07} {FCM} {Mouse}
[IF={{ 7.7 }}] {Runmin Wu. et al. Protective effects of jiawei yupingfeng polysaccharides on cyclophosphamide-induced intestinal injury in mice. INT J BIOL MACROMOL. 2025 May;310:143405} {WB} {Mouse}
[IF={{ 6.1 }}] {Mingxin Huang. et al. 3-Hydroxybutyrate ameliorates sepsis-associated acute lung injury by promoting autophagy through the activation of GPR109α in macrophages. BIOCHEM PHARMACOL. 2023 May;:115632} {WB} {Mouse}
[IF={{ 5.6 }}] {Jiancheng Qi. et al. Low Glucose plus β-Hydroxybutyrate Induces an Enhanced Inflammatory Response in Yak Alveolar Macrophages via Activating the GPR109A/NF-κB Signaling Pathway. INT J MOL SCI. 2023 Jan;24(14):11331} {WB} {Bovine}
[IF={{ 3.6 }}] {Xu Qiu. et al. 3-Hydroxybutyrate Promotes Myoblast Proliferation and Differentiation through Energy Metabolism and GPR109a-Mediated Ca2+-NFAT Signaling Pathways. J PROTEOME RES. 2025;24(4):2063–2080} {WB} {Mouse}
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GPR109A Rabbit pAb(bs-10079R)-50ul/100ul/200ul
￥1180 - 2800
