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| 规格： | 50ul | 产品价格： | ￥1180.0 |
|---|---|---|---|
| 规格： | 100ul | 产品价格： | ￥1980.0 |
| 规格： | 200ul | 产品价格： | ￥2800.0 |
| 产品编号 | bs-1273R |
| 英文名称 | E-Selectin Rabbit pAb |
| 中文名称 | E选择素抗体 |
| 英文别名 | CD 62E; CD26E; CD62E antigen; CD62 antigen-like family member E; E selectin; ELAM 1; ELAM; ELAM-1; ELAM1; Endothelial adhesion molecule 1; Endothelial leukocyte adhesion molecule 1; ESEL; LECAM 2; LECAM2; Leukocyte endothelial cell adhesion molecule 2; Leukocyte-endothelial cell adhesion molecule 2; LYAM2_HUMAN; SELE; Selectin E; SelectinE. |
| 产品应用 | WB=1:500-2000, IHC-P=1:100-500, IHC-F=1:100-500, IF=1:100-500 Not yet tested in other applications. |
| 交叉反应 | Human |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from mouse E-Selectin |
| 亚型 | IgG |
| 性状 | Liquid |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 理论分子量 | 65 kDa |
| 实际分子量 | 115 kDa |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Cardiovascular > Angiogenesis > Endothelial Cell Markers Cardiovascular > Atherosclerosis > Vascular Inflammation > Leukocyte recruitment > Cell adhesion molecules Cardiovascular > Cardiovascular Markers > Cell Markers > Endothelial Cells Immunology > Cell Type Markers > CD > Adhesion Kits/ Lysates/ Other > Kits > ELISA Kits > ELISA Kits > Adhesion molecules ELISA kits Kits/ Lysates/ Other > Kits > ELISA Kits > ELISA Kits > CD markers ELISA kits Stem Cells > Endothelial Progenitors > Endothelial Markers |
| 亚基 | Interacts with PSGL1/SELPLG through the sialyl Lewis X epitope. PSGL1 sulfation appears not to be required for this interaction. |
| 亚细胞定位 | Membrane; Single-pass type I membrane protein. |
| 相似性 | Belongs to the selectin/LECAM family. Contains 1 C-type lectin domain. Contains 1 EGF-like domain. Contains 6 Sushi (CCP/SCR) domains. |
| 功能 | Cell-surface glycoprotein having a role in immunoadhesion. Mediates in the adhesion of blood neutrophils in cytokine-activated endothelium through interaction with PSGL1/SELPLG. May have a role in capillary morphogenesis. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | The protein encoded by this gene is found in cytokine-stimulated endothelial cells and is thought to be responsible for the accumulation of blood leukocytes at sites of inflammation by mediating the adhesion of cells to the vascular lining. It exhibits structural features such as the presence of lectin- and EGF-like domains followed by short consensus repeat (SCR) domains that contain 6 conserved cysteine residues. These proteins are part of the selectin family of cell adhesion molecules. Adhesion molecules participate in the interaction between leukocytes and the endothelium and appear to be involved in the pathogenesis of atherosclerosis. [provided by RefSeq, Jul 2008] |
| 应用 | 推荐稀释比例 |
| {WB} | {1:500-2000} |
| {IHC-P} | {1:100-500} |
| {IHC-F} | {1:100-500} |
| {IF} | {1:100-500} |
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文献和实验[IF={{ 6.408 }}] {Zhao, Lixin. et al. A nanozyme-based competitive electrochemical immunosensor for the determination of E-selectin. MICROCHIM ACTA. 2022 Nov;189(11):1-10} {Other} {Human}
[IF={{ 6.1 }}] {Jun Zhang. et al.Parthenolide improves sepsis-induced coagulopathy by inhibiting mitochondrial-mediated apoptosis in vascular endothelial cells through BRD4/BCL-xL pathway.JOURNAL OF TRANSLATIONAL MEDICINE.2025 Jan 17;23(1):80.} {} {Rat}
[IF={{ 6.1 }}] {Yiyan Xie. et al. Portable pH meter-based competitive immunoassay of E-selectin using urease-encapsulated metal-organic frameworks. TALANTA. 2025 Jan;:127613} {} {}
[IF={{ 6.1 }}] {Yiyan Xie. et al. Portable pH meter-based competitive immunoassay of E-selectin using urease-encapsulated metal-organic frameworks. TALANTA. 2025 Jan;:127613} {} {}
[IF={{ 5.201 }}] {Qian Liet al. LOX-1 Regulates P. gingivalis-Induced Monocyte Migration and Adhesion to Human Umbilical Vein Endothelial Cells. Front Cell Dev Biol . 2020 Jul 14;8:596.} {WB} {Human}
Generation of Rabbit Immune Libraries
Rabbits provide an interesting alternative to antibodies derived from the murine system. Furthermore, rabbits show an exceptional feature with respect to the mechanisms that are used for the generation of antibody diversity, i.e. a single VH
In Vitro Translation Using Rabbit Reticulocyte Lysate
. This eliminates any background translation products. Several factors are added to rabbit reticulocyte lysate to optimize translation efficiency. These include hemin (to prevent phosphorylation of initiation factor eIF2-a), an energy-generating system (e.g
In Vitro Translation of mRNA in a Rabbit Reticulocyte Lysate Cell-Free System
components necessary for protein synthesis, i.e., ribosomes, tRNA, rRNA, amino acids, initiation, elongation and termination factors, and the energy-generating system (1 ). Heterologous mRNAs are faithfully and efficiently translated in extracts of HeLa
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