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活化半胱胺酸蛋白酶蛋白-3抗体

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活化半胱胺酸蛋白酶蛋白-3抗体

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  • 入驻年限  3年
  • 北京市通州区马驹桥镇联东U谷西区二号院67号楼

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  • 货号: bs-0081R
    抗体名: 活化半胱胺酸蛋白酶蛋白-3抗体
    抗体英文名: APCCaspase-3
    靶点: Caspase-3
    浓度: 1mg/ml
    应用范围: WB:1:500-2000 IHC-P:1:400-800 IHC-F:1:400-800 IF:1:100-500 Flow-Cyt:2μg/Test ELISA:1:500-1000
    宿主: Rabbit
    供应商: 北京博奥森生物技术有限公司
    数量: 100
    级别: 生产厂家
    目录编号: bs-0081R
    抗原来源: KLH conjugated synthetic peptide derived from human caspase-3 p17 subunit
    保质期: 一年
    适应物种: Human,Mouse,Rat,Dog,Pig,Cow,Horse,Rabbit,Sheep,
    标记物:
    克隆性: 单克隆
    保存条件: Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
    形态: Lyophilized or Liquid
    亚型: IgG
    免疫原: KLH conjugated synthetic peptide derived from human caspase-3 p17 subunit
    规格: 20ul/50ul/100ul/200ul
    规格: 20ul 产品价格: ¥480.0
    规格: 50ul 产品价格: ¥880.0
    规格: 100ul 产品价格: ¥1580.0
    规格: 200ul 产品价格: ¥2480.0
    The caspase family of cysteine proteases play a key role in apoptosis. Caspase 3 is the most extensively studied apoptotic protein among caspase family members. Caspase 3 is synthesized as inactive pro enzyme that is processed in cells undergoing apoptosis by self proteolysis and/or cleavage by other upstream proteases (e.g. Caspases 8, 9 and 10). The processed form of Caspase 3 consists of large (17kDa) and small (12kDa) subunits which associate to form an active enzyme. Caspase 3 is cleaved at Asp28 Ser29 and Asp175 Ser176. The active Caspase 3 proteolytically cleaves and activates other caspases (e.g. Caspases 6, 7 and 9), as well as relevant targets in the cells (e.g. PARP and DFF). Alternative splicing of this gene results in two transcript variants which encode the same protein. In immunohistochemical studies Caspase 3 expression has been shown to be widespread but not present in all cell types (e.g. commonly reported in epithelial cells of skin, renal proximal tubules and collecting ducts). Differences in the level of Caspase 3 have been reported in cells of short lived nature (eg germinal centre B cells) and those that are long lived (eg mantle zone B cells). Caspase 3 is the predominant caspase involved in the cleavage of amyloid beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease.
    Reacts with Caspase-3 subunit p17 and precursor.

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