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- bs-12713R
- 2025年10月24日
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- 规格：
50ul/100ul/200ul
| 规格： | 50ul | 产品价格： | ￥1180.0 |
|---|---|---|---|
| 规格： | 100ul | 产品价格： | ￥1980.0 |
| 规格： | 200ul | 产品价格： | ￥2800.0 |
| 产品编号 | bs-12713R |
| 英文名称 | PLCD3 Rabbit pAb |
| 中文名称 | 磷酸肌醇磷脂酶c-delta-3抗体 |
| 英文别名 | PLC-delta-3; 1-phosphatidylinositol-4; 5-bisphosphate phosphodiesterase delta-3; phosphoinositide phospholipase C-delta-3; phospholipase C-delta-3; PLC-delta-3; PLCD3; PLCD3_HUMAN. |
| 产品应用 | IHC-P=1:100-500, IHC-F=1:100-500, ICC/IF=1:100-500, IF=1:100-500, ELISA=1:5000-10000 Not yet tested in other applications. |
| 交叉反应 | (Human, Mouse, Rat, Dog, Pig, Horse, Rabbit) |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human PLCD3 |
| 亚型 | IgG |
| 性状 | Liquid |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 理论分子量 | 89 kDa |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Signal Transduction > Second Messenger > Lipid Messengers Signal Transduction > Signaling Pathway > Calcium Signaling > Calcium Binding Proteins Signal Transduction > Signaling Pathway > Lipid Signaling |
| 亚细胞定位 | Membrane. Cytoplasm. Cleavage furrow. Localizes at the cleavage furrow during cytokinesis. |
| 组织特异性 | Present in corneal epithelial cells (at protein level). |
| 相似性 | Contains 1 C2 domain. Contains 3 EF-hand domains. Contains 1 PH domain. Contains 1 PI-PLC X-box domain. Contains 1 PI-PLC Y-box domain. |
| 功能 | Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Essential for trophoblast and placental development. May participate in cytokinesis by hydrolyzing PIP2 at the cleavage furrow. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | This gene encodes a member of the phospholipase C family, which catalyze the hydrolysis of phosphatidylinositol 4,5-bisphosphate to generate the second messengers diacylglycerol and inositol 1,4,5-trisphosphate (IP3). Diacylglycerol and IP3 mediate a variety of cellular responses to extracellular stimuli by inducing protein kinase C and increasing cytosolic Ca(2+) concentrations. This enzyme localizes to the plasma membrane and requires calcium for activation. Its activity is inhibited by spermine, sphingosine, and several phospholipids. [provided by RefSeq, Jul 2008 |
| 应用 | 推荐稀释比例 |
| {IHC-P} | {1:100-500} |
| {IHC-F} | {1:100-500} |
| {ICC/IF} | {1:100-500} |
| {IF} | {1:100-500} |
| {ELISA} | {1:5000-10000} |
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文献和实验该产品被引用文献
[IF={{ 2.2 }}] {Yu Yantao. et al. PLCD3 inhibits apoptosis and promotes proliferation, invasion and migration in gastric cancer. Discover Oncology. 2024 Dec;15(1):1-17} {IF} {Human}
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PLCD3 Rabbit pAb(bs-12713R)-50ul/100ul/200ul
￥1180 - 2800
