PELI2 | Pellino-2 Rabbit pAb(bs-12615R)-50ul/100ul/200ul产品图

PELI2 | Pellino-2 Rabbit pAb(b

s-12615R)-50ul/100ul/200ul
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  • ¥1180 - 2800
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  • bs-12615R
  • 2026年10月13日
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    • 规格:

      50ul/100ul/200ul

    规格:50ul产品价格:¥1180.0
    规格:100ul产品价格:¥1980.0
    规格:200ul产品价格:¥2800.0
    产品编号bs-12615R
    英文名称Pellino 2 Rabbit pAb
    中文名称Pellino 2蛋白抗体
    英文别名E3 ubiquitin-protein ligase pellino homolog 2; PELI2; pellino E3 ubiquitin protein ligase family member 2; Pellino homolog 2.
    产品应用WB=1:500-2000

    Not yet tested in other applications.
    Optimal working dilutions must be determined by the end user.

    交叉反应Mouse (Human, Chicken, Pig, Cow, Horse, Sheep)
    抗体来源Rabbit
    免疫原KLH conjugated synthetic peptide derived from human Pellino 2
    亚型IgG
    性状Liquid
    纯化方法affinity purified by Protein A
    克隆类型Polyclonal
    理论分子量46 kDa
    浓度1mg/ml
    储存液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
    研究领域

    Epigenetics and Nuclear Signaling > Cell cycle > Kinases/Phosphatases

    Signal Transduction > Protein Phosphorylation > Ser / Thr Kinases > MAPK Pathway

    亚基Interacts with TRAF6, IRAK1, IRAK4 and MAP3K7. Interacts with BCL10; this interaction is impaired by SOCS3 (By similarity).
    翻译后修饰Phosphorylated by IRAK1 and IRAK4 enhancing its E3 ligase activity.
    相似性Belongs to the pellino family.
    _x000D_ Contains 1 FHA domain.
    功能E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates IL1B-induced IRAK1 'Lys-63'-linked polyubiquitination and possibly 'Lys-48'-linked ubiquitination. May be important for LPS- and IL1B-induced MAP3K7-dependent, but not MAP3K3-dependent, NF-kappa-B activation. Can activate the MAP (mitogen activated protein) kinase pathway leading to activation of ELK1.
    保存条件Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
    注意事项This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
    背景资料Scaffold protein which probably links Toll like receptors (TLRs) to basic cellular processes via its interaction with the complex containing IRAK (IL1R associated kinase) kinases and TRAF6. Can activate the MAP (mitogen activated protein) kinase pathway leading to activation of ELK1. Not required for NF-kappa-B activation.

     

    应用推荐稀释比例
    {WB}{1:500-2000}

     

    产品细节图片1
    Sample: Embryo (mouse) Lysate at 40 ug
    _x000D_ Primary: Anti-Pellino2 (bs-12615R) at 1/300 dilution
    _x000D_ Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
    _x000D_ Predicted band size: 46 kD
    _x000D_ Observed band size: 46 kD

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    PELI2 | Pellino-2 Rabbit pAb(bs-12615R)-50ul/100ul/200ul
    ¥1180 - 2800