KAT4/TAF1 Rabbit pAb(bs-2812R)-50ul/100ul

KAT4/TAF1 Rabbit pAb(bs-2812R)

-50ul/100ul
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  • ￥1180 - 1980
  • Bioss已认证
  • bs-2812R
  • 2025年10月24日
  • 产品信息以Bioss网站为准
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北京博奥森生物技术有限公司
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    • 规格：

      50ul/100ul

    规格：50ul产品价格：￥1180.0
    规格：100ul产品价格：￥1980.0
    产品编号bs-2812R
    英文名称KAT4/TAF1 Rabbit pAb
    中文名称细胞周期基因1蛋白抗体
    英文别名TBP Associated Factor 1; BA2R; CCG 1; CCG1; CCGS; Cell cycle G1 phase defect; Cell cycle gene 1 protein; Complementation of cell cycle block G1 to S; DYT3 protein; NSCL 2; NSCL2; OF; p250; TAF 1; TAF 2A; TAF(II)250; TAF1; TAF1 RNA polymerase II TATA box binding protein(TBP) associated factor 250kDa; TAF1 RNA polymerase II TATA box binding protein(TBP) associated factor; TAF1 RNA polymerase II TATA box binding protein associated factor 250kDa; TAF1_HUMAN; TAF2A; TAFII 250; TAFII-250; TAFII250; TAF II P250; TATA box binding protein(TBP) associated factor RNA polymerase II A; TATA box binding protein(TBP) associated factor RNA polymerase II A 250kD; TBP associated factor 250 kDa; TBP-associated factor 250 kDa; Transcription factor TFIID p250 polypeptide; Transcription initiation factor TFIID 250 kDa subunit; Transcription initiation factor TFIID subunit 1.
    产品应用WB=1:500-2000, IHC-P=1:100-500, IHC-F=1:100-500, IF=1:100-500, ELISA=1:5000-10000

    Not yet tested in other applications.
    Optimal working dilutions must be determined by the end user.

    交叉反应Human (Mouse, Rat, Chicken, Dog, Cow, Horse)
    抗体来源Rabbit
    免疫原KLH conjugated synthetic peptide derived from human TAF1
    亚型IgG
    性状Liquid
    纯化方法affinity purified by Protein A
    克隆类型Polyclonal
    理论分子量200 kDa
    实际分子量250-300 kDa
    浓度1mg/ml
    储存液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
    研究领域

    Epigenetics and Nuclear Signaling > Chromatin Modifying Enzymes > Acetylation

    Epigenetics and Nuclear Signaling > Chromatin Modifying Enzymes > Acetylation > HAT

    Epigenetics and Nuclear Signaling > Transcription > Polymerase associated factors > Pol II Transcription > TFIID

    亚基TAF1 is the largest component of transcription factor TFIID that is composed of TBP and a variety of TBP-associated factors. TAF1, when part of the TFIID complex, interacts with C-terminus of TP53. Component of some MLL1/MLL complex, at least composed of the core components MLL, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components C17orf49, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, KAT8/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. RB1 interacts with the N-terminal domain of TAF1. Interacts with ASF1A and ASF1B. Interacts with SV40 Large T antigen.
    亚细胞定位Nucleus.
    翻译后修饰Phosphorylated by casein kinase II in vitro.
    相似性Belongs to the TAF1 family.
    Contains 2 bromo domains.
    Contains 1 HMG box DNA-binding domain.
    Contains 2 protein kinase domains.
    功能Largest component and core scaffold of the TFIID basal transcription factor complex. Contains novel N- and C-terminal Ser/Thr kinase domains which can autophosphorylate or transphosphorylate other transcription factors. Phosphorylates TP53 on 'Thr-55' which leads to MDM2-mediated degradation of TP53. Phosphorylates GTF2A1 and GTF2F1 on Ser residues. Possesses DNA-binding activity. Essential for progression of the G1 phase of the cell cycle.
    保存条件Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
    注意事项This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
    背景资料Largest component and core scaffold of the TFIID basal transcription factor complex. Contains novel N- and C-terminal Ser/Thr kinase domains which can autophosphorylate or transphosphorylate other transcription factors. Phosphorylates TP53 on 'Thr-55' which leads to MDM2-mediated degradation of TP53. Phosphorylates GTF2A1 and GTF2F1 on Ser residues. Possesses DNA-binding activity. Essential for progression of the G1 phase of the cell cycle.

     

    应用推荐稀释比例
    {WB}{1:500-2000}
    {IHC-P}{1:100-500}
    {IHC-F}{1:100-500}
    {IF}{1:100-500}
    {ELISA}{1:5000-10000}

     

    KAT4/TAF1 Rabbit pAb(bs-2812R)
    P‌‌araformaldehyde-fixed, paraffin embedded (human brain glioma); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (KAT4) Polyclonal Antibody, Unconjugated (bs-2812R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
    KAT4/TAF1 Rabbit pAb(bs-2812R)
    Sample:
    Lane 1: Human 293T cell lysates
    Lane 2: Human HeLa cell lysates
    Primary: Anti-KAT4/TAF1 (bs-2812R) at 1/1000 dilution
    Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
    Predicted band size: 200 kDa
    Observed band size: 300 kDa
    KAT4/TAF1 Rabbit pAb(bs-2812R)
    P‌‌araformaldehyde-fixed, paraffin embedded (human laryngeal carcinoma); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Incubation with (KAT4) Polyclonal Antibody, Unconjugated (bs-2812R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
    KAT4/TAF1 Rabbit pAb(bs-2812R)
    P‌‌araformaldehyde-fixed, paraffin embedded (human breast carcinoma); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Incubation with (KAT4) Polyclonal Antibody, Unconjugated (bs-2812R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.

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    KAT4/TAF1 Rabbit pAb(bs-2812R)-50ul/100ul
    ￥1180 - 1980