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- 2025年10月16日
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50ul/100ul/200ul
| 规格： | 50ul | 产品价格： | ￥1180.0 |
|---|---|---|---|
| 规格： | 100ul | 产品价格： | ￥1980.0 |
| 规格： | 200ul | 产品价格： | ￥2800.0 |
| 产品编号 | bs-8615R |
| 英文名称 | Ribonuclease 3/ECP Rabbit pAb |
| 中文名称 | 嗜酸性粒细胞阳离子蛋白抗体 |
| 英文别名 | eosinophil cationic protein; EAR; Ear11; Ear4; EAR5; ECP; LOC192264; MGC143624; mR3; mR5; R1; R14; R15; R17; R5; R7; Ribonuclease 3; Rnase17; Rnase2; RNASE3; RNS3; ECP_HUMAN. |
| 产品应用 | WB=1:500-2000, ICC/IF=1:100-500 Not yet tested in other applications. |
| 交叉反应 | Human |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human Ribonuclease 3 |
| 亚型 | IgG |
| 性状 | Liquid |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 理论分子量 | 16 kDa |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 亚细胞定位 | Cytoplasmic granule. Matrix of eosinophil's large specific granule. |
| 相似性 | Belongs to the pancreatic ribonuclease family. |
| 功能 | Cytotoxin and helminthotoxin with low-efficiency ribonuclease activity. Possesses a wide variety of biological activities. Exhibits antibacterial activity. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | ECP is a 160 amino acid potent cytotoxic secretory protein that belongs to the pancreatic ribonuclease family. ECP localizes to the granule matrix of the eosinophil and is involved in the immune response system. ECP is a cytotoxin, neurotoxin and helminthotoxin that is secreted by activated human eosinophils. ECP exhibits anti-parasitic, antibacterial and ribonucleolytic activities. It has been suggested that ECP induces the neurotoxic effect known as the Gordon phenomenon, a syndrome manifested by ataxia, muscular rigidity, paralysis, and tremor that may lead to death. ECP is considered a marker of eosinophilic inflammation and high levels have been found in cases of active asthma and other allergic diseases |
| 应用 | 推荐稀释比例 |
| {WB} | {1:500-2000} |
| {ICC/IF} | {1:100-500} |
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文献和实验[IF={{ 5.3 }}] {Seo-Hee Kim. et al. The effect of apigenin, an aryl hydrocarbon receptor antagonist, in Phthalate-Exacerbated eosinophilic asthma model. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE. 2023 Jun;27(13):1900-1910} {WB} {Mouse}
[IF={{ 4.7 }}] {Francesca Bertolini. et al.Vascular remodeling and TSLP/angiogenin overexpression in severe mixed asthma.RESPIRATORY RESEARCH.2025 Feb 28;26(1):78.} {Western blot} {Human}
[IF={{ 4.082 }}] {Yoshimasa Imoto. et al. Enhanced 15-Lipoxygenase 1 Production is Related to Periostin Expression and Eosinophil Recruitment in Eosinophilic Chronic Rhinosinusitis. Biomolecules. 2020 Nov;10(11):1568} {IF} {Human}
[IF={{ 2.36 }}] {Inada, Noriko, et al. "Histamine H 1 and H 4 receptor expression on the ocular surface of patients with chronic allergic conjunctival diseases." Allergology International (2017).} {ICC} {="Human"}
[IF={{ 2.36 }}] {Tokunaga, Takahiro, et al. "The significant expression of TRPV3 in nasal polyps of eosinophilic chronic rhinosinusitis." Allergology International (2017).} {IHC} {="Human"}
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