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50ul/100ul/200ul
| 规格： | 50ul | 产品价格： | ￥1180.0 |
|---|---|---|---|
| 规格： | 100ul | 产品价格： | ￥1980.0 |
| 规格： | 200ul | 产品价格： | ￥2800.0 |
| 产品编号 | bs-11834R |
| 英文名称 | DYRK1A Rabbit pAb |
| 中文名称 | 丝氨酸/苏氨酸蛋白激酶MNB抗体 |
| 英文别名 | Dual specificity tyrosine phosphorylation regulated kinase 1A; DYRK 1; DYRK 1A; DYRK; DYRK1; DYRKA; HP 86; HP86; Minibrain(Drosophila) homolog; Minibrain homolog; MNB; MNB/DYRK protein kinase antibody; MNBH; Protein kinase minibrain homolog; Serine/threonine kinase MNB; DYR1A_HUMAN. |
| 产品应用 | WB=1:500-2000, IHC-P=1:100-500, IHC-F=1:100-500, ICC/IF=1:100-500, IF=1:100-500, ELISA=1:5000-10000 Not yet tested in other applications. |
| 交叉反应 | (Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep) |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human DYRK1A |
| 亚型 | IgG |
| 性状 | Liquid |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 理论分子量 | 86 kDa |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Microbiology > Organism > Virus > RNA Virus > ssRNA positive strand virus > SARS Coronavirus Neuroscience > Neurology process > Neurogenesis |
| 亚基 | Interacts RAD54L2/ARIP4 (By similarity). Interacts with RANBP9. Interacts with WDR68. |
| 亚细胞定位 | Nucleus speckle. |
| 组织特异性 | Ubiquitous. Highest levels in skeletal muscle, testis, fetal lung and fetal kidney. |
| 翻译后修饰 | Autophosphorylated on tyrosine residues. |
| 相似性 | Contains 1 protein kinase domain. |
| 功能 | DYRK1A, the vertebrate of Drosophilia Minibrain, is a dual-specificity kinase predominately expressed in the central nervous system. The human clone has been isolated from the Downs' syndrome critical region and it is potentially implicated in the neuropathology of the disease. Main features of the protein include an N-terminal nuclear translocation signal, a putative leucine zipper domain, a core kinase domain with some similarity to kinases involved in cell cycle regulation and a C-terminal PEST sequence. The DYRK1A kinase can be phosphorylated on tyrosine residues, leading to an active kinase that can phosphorylated itself or exogenous substrates on both tyrosine and serine/threonine residues. DYRK1A can also multimerize and translocate to the nucleus. Present studies on DYRK1A suggest a potential role for this kinase in the exit from the cell cycle and the beginning of neuronal differentiation. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Dyrk (for dual specificity tyrosine phosphorylation regulated kinase) is the homolog of the Drosophila mnb (minibrain) gene which is required for neurogenesis. Dyrk is a dual-specificity tyrosine kinase and serine/threonine kinase, which is itself regulated by tyrosine phosphorylation. Several mammalian Dyrk related proteins have been identified and are thought to compose a family of dual specificity protein kinases. Dyrk family members, including Dyrk1A (dual specificity tyrosine-phosphorylation-regulated kinase 1A), Dyrk1B, Dyrk1C, Dyrk2, Dyrk3, Dyrk4A and Dyrk4B, are thought to be involved in diverse cellular functions. Localized to the nucleus and highly expressed in testis, muscle and the developing nervous system, Dyrk1A, also known as MNB or MNBH, functions to phosphorylate serine, threonine and tyrosine residues on various substrates involved in signaling pathways that regulate cell proliferation. Dyrk1A is a candidate gene for learning defects that are involved in Downs syndrome (DS), suggesting a possible role for Dyrk1A in the development of DS. Four isoforms of Dyrk1A exist due to alternative splicing events. |
| 应用 | 推荐稀释比例 |
| {WB} | {1:500-2000} |
| {IHC-P} | {1:100-500} |
| {IHC-F} | {1:100-500} |
| {ICC/IF} | {1:100-500} |
| {IF} | {1:100-500} |
| {ELISA} | {1:5000-10000} |
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文献和实验[IF={{ 5.273 }}] {Xin Liu. et al. An inhibitor with GSK3β and DYRK1A dual inhibitory properties reduces Tau hyperphosphorylation and ameliorates disease in models of Alzheimer's disease. NEUROPHARMACOLOGY. 2023 Jul;232:109525} {WB} {Human}
[IF={{ 4.8 }}] {Lu Wang. et al.TOM1L1 mediated the sort of tumor suppressive miR-378a-3p into exosomes and the excretion out of cells to promote ESCC progression..CANCER GENE THERAPY.2025 Mar 23.} {IHC} {Mouse}
[IF={{ 4.5 }}] {Li Guan. et al. Design, synthesis, and biological evaluation of β-carboline-cinnamic acid derivatives as DYRK1A inhibitors in the treatment of diabetes. BIOORG CHEM. 2024 Oct;151:107676} {WB} {Mouse}
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