Sample:
Lane 1: Human K562 cell Lysates
Lane 2: Human THP-1 cell Lysates
Lane 3: Human Jurkat cell Lysates
Primary: Anti-IL-10RA (bs-2459R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 60kDa
Observed band size: 55kDa
- ￥1180 - 2800
- Bioss
- bs-2459R
- 2025年10月24日
- 产品信息以Bioss网站为准
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- 应用范围：
产品信息以Bioss网站为准
- 规格：
50ul/100ul/200ul
| 规格： | 50ul | 产品价格： | ￥1180.0 |
|---|---|---|---|
| 规格： | 100ul | 产品价格： | ￥1980.0 |
| 规格： | 200ul | 产品价格： | ￥2800.0 |
| 产品编号 | bs-2459R |
| 英文名称 | IL-10RA Rabbit pAb |
| 中文名称 | 白细胞介素-10受体a抗体 |
| 英文别名 | Interleukin-10 Receptor; CD210; CDW210A; CDw210a; CDw210a antigen; HIL 10R; HIL10R; IL 10R 1; IL 10R A; IL 10R; IL10RA; IL 10R1; IL10R; IL10R1; Interleukin 10 receptor alpha; Interleukin 10 receptor alpha chain; I10R1_HUMAN; Interleukin-10 receptor subunit alpha; IL-10 receptor subunit alpha; IL-10R subunit alpha; IL-10RA; Interleukin-10 receptor bunit 1; IL-10R subunit 1; IL-10R1. |
| 产品应用 | WB=1:500-2000 Not yet tested in other applications. |
| 交叉反应 | Human (Mouse, Rat, Pig, Cow) |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human IL-10RA |
| 亚型 | IgG |
| 性状 | Liquid |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 理论分子量 | 60 kDa |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Immunology > Innate Immunity > Cytokines > Interleukins |
| 亚细胞定位 | Membrane; Single-pass type I membrane protein. |
| 组织特异性 | Spleen, thymus, and PBMC. Weak expression in pancreas, skeletal muscle, brain, heart, and kidney. Placenta, lung, and liver showed intermediate levels. Monocytes, B-cells, large granular lymphocytes, and T-cells express high levels. |
| 相似性 | Belongs to the type II cytokine receptor family. |
| 功能 | Receptor for IL10; binds IL10 with a high affinity. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | The protein encoded by this gene is a receptor for interleukin 10. This protein is structurally related to interferon receptors. It has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. This receptor is reported to promote survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of this receptor leads to tyrosine phosphorylation of JAK1 and TYK2 kinases. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene. [provided by RefSeq]. |
| 应用 | 推荐稀释比例 |
| {WB} | {1:500-2000} |
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文献和实验该产品被引用文献
[IF={{ 6.3 }}] {Qi Li. et al. Identification of inflammation-related biomarkers and therapeutic targets for neurogenic bladder fibrosis via multi-omics analysis. COMPUT BIOL MED. 2025 Sep;196:110721} {WB} {Human}
[IF={{ 4.285 }}] {Han Jisoo. et al. Interleukin-10 and Its Receptors at the Maternal-Conceptus Interface: Expression, Regulation, and Implication for Th2 Cytokine Predominance and Maternal Immune Tolerance in the Pig, a True Epitheliochorial Placentation Species. Biol Reprod. 2022 Mar;:} {IHC} {Pig}
[IF={{ 3.514 }}] {Segiet A et al. Tumour necrosis factor and interleukin 10 in blood pressure regulation in spontaneously hypertensive and normotensive rats.Cytokine. 2019 Jan;113:185-194.} {IF} {Rat}
[IF={{ 1.672 }}] {Talya Wittmann Dayagi. et al. Mucosal IL‐10 and IL‐10 receptor expression patterns in paediatric patients with ulcerative colitis. Int J Exp Pathol. 2021 Feb;102(1):4-10} {IHC} {Human}
相关实验
20世纪70年代，在研究发热机制时发现了一类名为“白细胞热原”的分子。20世纪80年代，这类分子被纯化并鉴定为IL-1α和IL-1β。它们通过共同的受体IL-1R1发挥作用，是IL-1细胞因子家族的核心成员。该家族现已扩展至11种具有无活性前体结构的细胞因子（含促炎与抗炎类型）及10种多链受体，还包括两个诱饵受体、一个抑制性蛋白和两个受体拮抗剂，其中IL-1RA最为著名，可天然抑制IL-1R1的激活。多种功能协同或拮抗的成员共存，凸显该家族生物学功能的复杂性与调控的精密性。 IL-1家族 IL-
抗体 (ACPA) 等针对自身组织的抗体，并持续释放 TNF-α、IL-1 等大量促炎因子，从而导致滑膜出现持续性炎症，进而引发关节软骨和骨破坏[1]。类风湿性关节炎患者的关节肿胀反映了由于免疫激活而引起的滑膜炎症。 图 1. 正常关节与类风湿性关节炎关节[1]。 Section.02 RA 药物发展 在 20 世纪 90 年代初，糖皮质激素 (Cs) 或 NSAIDs (非甾体抗炎药)、是治疗类风湿关节炎的主要手段。 近几十年来，则以改善病情抗风湿药 (DMARDs
= NAL), appears to form upon oxidative cyclization of the nonfluorescent 2:1 lysine-HNE Michael adduct-Schiff base cross-link (Scheme 1). Polyclonal antibody (PAb) to the NAL-HNE fluorophore was raised in rabbit and found to be highly specific
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IL-10RA Rabbit pAb(bs-2459R)-50ul/100ul/200ul
￥1180 - 2800
