A synthetic peptide corresponding to residues near the N-terminus region of human EYA2
应用范围:
WB, IP
宿主:
Rabbit Monoclonal IgG
抗原来源:
human
适应物种:
Human
供应商:
上海博迈生物科技有限公司
库存:
大量
是否单克隆:
0
规格:
100µl
EYA2 (eyes absent homolog 2) is a human homologue of the Drosophila Eya transcription co-activator. EYA2 is a cytosolic tyrosine phosphatase which translocates to the nucleaus by the Six homeodomain-containing family of proteins, where it becomes cofactor for the transcription factor SIX1. Specifically, EYA2 dephosphorylates tyrosine 142 of histone H2AX and, therefore, it is thought to be involved in transcription regulation during organogenesis. Also, together with SIX1 and DACH2, EYA2 seems to be involved in myogensis. EYA2 translocation and transcriptional activity are inhibited by its direct interaction with activated GNAZ and GNAI2. EYA2 might be involved in the development of eye (1, 2).