- ￥525 - 4343
- TargetMol
- USA
- T2241
- 2025年07月12日
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- 详细信息
- 技术资料
- 保存条件：
-20°C
- 保质期：
For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -2261℃ for several months.
- 英文名：
MLN8237(Alisertib)
- 库存：
详询
- 供应商：
详询
- CAS号：
1028486-01-2
- 规格：
2mg/5mg/10mg/50mg/1ml/10mM
| 规格： | 2mg | 产品价格： | ￥525.0 |
|---|---|---|---|
| 规格： | 5mg | 产品价格： | ￥838.0 |
| 规格： | 10mg | 产品价格： | ￥1313.0 |
| 规格： | 50mg | 产品价格： | ￥4343.0 |
| 规格： | 1ml/10mM | 产品价格： | ￥834.0 |
ID：T2241
PURITY：97%+
Formula：C27H20ClFN4O4
MolWt：518.9235032
Appearance：黄色粉末
Solubility：G4Soluble in DMSO
Bioactivity：Alisertib is a second-generation, orally bioavailable, highly selective small molecule inhibitor of the serine/threonine protein kinase Aurora A kinase with potential antineoplastic activity. Alisertib binds to and inhibits Aurora A kinase, which may result in disruption of the assembly of the mitotic spindle apparatus, disruption of chromosome segregation, and inhibition of cell proliferation. Aurora A kinase localizes to the spindle poles and to spindle microtubules during mitosis, and is thought to regulate spindle assembly. Aberrant expression of Aurora kinases occurs in a wide variety of cancers, including colon and breast cancers.
Status：
Pathways：Cell Cycle/Checkpoint
Target：Aurora Kinase inhibitor
Receptor：Aurora A, Aurora B
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