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- 详细信息
- 文献和实验
- 技术资料
- 保存条件:
2-8°C
- 保质期:
For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -1076℃ for several months.
- 英文名:
Fludarabine
- 库存:
详询
- 供应商:
详询
- CAS号:
21679-14-1
- 规格:
2mg/5mg/10mg/20mg/1ml/10mM
| 规格: | 2mg | 产品价格: | ¥208.0 |
|---|---|---|---|
| 规格: | 5mg | 产品价格: | ¥404.0 |
| 规格: | 10mg | 产品价格: | ¥707.0 |
| 规格: | 20mg | 产品价格: | ¥1212.0 |
| 规格: | 1ml/10mM | 产品价格: | ¥458.0 |
ID:T1038
PURITY:0.99
Formula:C10H12FN5O4
MolWt:285.23
Appearance:白色粉末
Solubility:G4Soluble in DMSO
Bioactivity:Purine analog that inhibits DNA synthesis. Exhibits antiproliferative activity and triggers apoptosis through increasing Bax and decreasing Bid, XIAP and survivin expression.
Status:USP, INN, BAN
Pathways:DNA Damage/DNA Repair;JAK/STAT Signaling
Target:DNA synthesis inhibitor;STAT inhibitor
Receptor:DNA Synthsis ;STAT1
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文献和实验过继转移的T细胞。获得的TIL进一步运用CD3单抗、外源性11_-2以及辐照过的同种异体的PBMC共同培养,进行选择性扩增(细胞数量可达到IOTM),在细胞过继转移之前测定细胞活性。在给患者输注淋巴细胞之前运用环磷酰胺或Fludarabine治疗去除患者体内的淋巴细胞但保留髓系细胞,或对患者全身辐照进行预处理等。 细胞过继治疗肿瘤的临床方案 从瘤组织中分离细胞,与自体或同系的MHC匹配的肿瘤细胞系进行培养,高水平分泌表达IFN-Y的淋巴细胞即为肿瘤
of de novo purine biosynthesis; and iii) inhibitors of the purine salvage pathway [11]. It was reported, for example, that the purine nucleoside analogues fludarabine and 2-chlorodeoxyadenosine are very active in chronic lymphocytic leukaemia (CLL
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