Wang-Ying Dai, et al. Biomed Res Int. 2022; 2022: 9471558. PMID: 35155682 Identification of Prognostic lncRNA Related to the Immune Microenvironment of Soft Tissue Sarcoma
HDF-a细胞介绍
华拓细胞库:HDF-a人真皮成纤维细胞 Human dermal fibroblasts were isolated from the dermis within the skin tissue. Skin tissue sources include head, face, hands, feet, legs, back, abdomen, prepuce and other body surface skin, which can be selected according to demand; The dermis, located deep in the epidermis, is connected downward to the subcutaneous tissue, and the collagen and elastic fibers of the dermal connective tissue are interwoven and buried in the stroma. It is distributed in a variety of connective tissue cells and a large number of collagen fibers elastic fibers, making the skin both elastic and toughness. It consists of two layers, the papillary layer and the reticular layer. The structure of the dermis is composed of collagen, elastic fibers and matrix. Fibroblast is the main cellular component of loose connective tissue, derived from embryonic mesenchymal cells. Fibroblasts are large and have clear outline. They are mostly spindle-shaped or star-shaped flat structures with regular oval nuclei and large and obvious nucleolus. Fibroblasts have strong functional activities, weak basophilic cytoplasm, and obvious protein synthesis and secretion activities. Under certain conditions, they can realize mutual transformation with fibroblasts. Fibroblasts play an important role in the repair of various degrees of cell degeneration, necrosis and tissue defect. The main functions of dermal fibroblasts under physiological conditions include: construction and maintenance of normal tissue morphology, synthesis and release of extracellular matrix, and timely mass accumulation after tissue injury to repair the injured tissue.
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