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文献和实验肺癌lung cancer,pulmonary carcinoma
发生于肺的癌瘤。特别是男性仅次于胃癌,欧美肺癌比胃癌多。在日本胃癌的增加趋势已停止,但肺癌却急剧增加。最多见于40—60岁。右肺多于左肺,上叶多于下叶。从支气管特别是粘膜上皮发生者占大部分,但亦可从肺泡上皮发生。支气管癌在组织学上可分为鳞状细胞癌、腺癌、未分化癌等。最近由于早期发现及外科手术(肺切除)的进步,治愈率逐渐上升。然而由于锁骨上窝淋巴结转移、癌性胸膜炎、纵膈障的压迫,骨、脑、肾上腺等的血行转移,多在半年或一年当中即死亡。肺癌和吸烟的关系受到重视,这不是由于尼古丁而是由于吸烟
PPAR/ Agonist Increases the Expression of PGE2 Receptor Subtype EP4 in Human Lung Carcinoma Cells
an important role in the effort to help extend its dismal 5-year survival rate (2 (PGE2 ), and the prostag-landin E2 receptor subtype, EP4, promote the growth and progression of human nonsmall cell lung carcinoma (NSCLC), the most common lung carcinoma
Lung-Specific Expression of Mutant p53 as Mouse Model for Lung Cancer
, there has been a concomitant change in the histologic type of lung cancer (4) . While SCLC has persisted at about 20%, adenocarcinoma has increased to 45% with declines in squamous cell and large cell carcinoma. Thun and colleagues (5) have suggested that these changes
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