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文献和实验肺癌lung cancer,pulmonary carcinoma
发生于肺的癌瘤。特别是男性仅次于胃癌,欧美肺癌比胃癌多。在日本胃癌的增加趋势已停止,但肺癌却急剧增加。最多见于40—60岁。右肺多于左肺,上叶多于下叶。从支气管特别是粘膜上皮发生者占大部分,但亦可从肺泡上皮发生。支气管癌在组织学上可分为鳞状细胞癌、腺癌、未分化癌等。最近由于早期发现及外科手术(肺切除)的进步,治愈率逐渐上升。然而由于锁骨上窝淋巴结转移、癌性胸膜炎、纵膈障的压迫,骨、脑、肾上腺等的血行转移,多在半年或一年当中即死亡。肺癌和吸烟的关系受到重视,这不是由于尼古丁而是由于吸烟
Lung-Specific Expression of Mutant p53 as Mouse Model for Lung Cancer
, there has been a concomitant change in the histologic type of lung cancer (4) . While SCLC has persisted at about 20%, adenocarcinoma has increased to 45% with declines in squamous cell and large cell carcinoma. Thun and colleagues (5) have suggested that these changes
Characteristic Genetic Alterations in Lung Cancer
leading to lung cancer is still rudimentary. Lung cancer is classified into two major clinic-pathological groups, small cell lung carcinoma (SCLC) and non-small cell lung carcinoma (NSCLC) (2 ). Squamous cell carcinoma, adenocarcinoma, and large cell
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