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- 2025年12月05日
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- 文献和实验
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
1207253-08-4
- 规格：
10 mM * 1 mL/1 mg/5 mg/10 mg/25 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥1728.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥690.0 |
| 规格： | 5 mg | 产品价格： | ￥1700.0 |
| 规格： | 10 mg | 产品价格： | ￥2720.0 |
| 规格： | 25 mg | 产品价格： | ￥4650.0 |
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MK-1064
CAS No. : 1207253-08-4
MCE 国际站：MK-1064
产品活性：MK-1064 是一种选择性的、具有口服活性的 OX2R 拮抗剂 (Ki: 0.5 nM, IC50: 18 nM)。MK-1064 可促进睡眠 (in vivo)。MK-1064 可用于神经相关的研究。
研究领域：GPCR/G Protein | Neuronal Signaling
作用靶点：Orexin Receptor (OX Receptor)
In Vivo: MK-1064 (30 mg/kg, oral administration) promotes sleep in rodents selectively through OX2R in Wild-type mice.
MK-1064 (30 mg/kg, oral administration, 5 days) reverses the struggle behavior induced by CNO pre-treatment in rats.
MK-1064 (1-5 mg/kg, intravenous injection/oral administration) shows moderate oral bioavailability and clearance in rat, dog, and rhesus monkey.
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文献和实验chain monoclonal antibody conjugated to horse-radish peroxidase (LO-MK1, LO/IMEX) 8. reveal with o-phenylenediamine dihydrochloride (OPD) in revelation solution. B. SOLUTIONS 1. PBS-PF (paraformaldehyde), 2% 2. PBS-tween 20, 0.05% 3. glycine (x
E L I S A w i t h p l a t e l e t s
for 1 hour with a 1 :1000 dilution of rat IgG2 a anti-mouse kappa chain monoclonal antibody conjugated to horse-radish peroxidase (LO-MK1 , LO/IMEX) reveal with o-phenylenediamine dihydrochloride (OPD) in revelation solution. SOLUTIONS
for 1 hour with a 1 :1000 dilution of rat IgG2 a anti-mouse kappa chain monoclonal antibody conjugated to horse-radish peroxidase (LO-MK1 , LO/IMEX) reveal with o-phenylenediamine dihydrochloride (OPD) in revelation solution. SOLUTIONS
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