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- 2025年12月05日
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- 保存条件：
4°C, sealed storage, away from moisture
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
23007-85-4
- 规格：
10 mM * 1 mL/5 mg/10 mg/25 mg/50 mg/100 mg/200 mg/500 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥715.0 |
|---|---|---|---|
| 规格： | 5 mg | 产品价格： | ￥406.0 |
| 规格： | 10 mg | 产品价格： | ￥650.0 |
| 规格： | 25 mg | 产品价格： | ￥980.0 |
| 规格： | 50 mg | 产品价格： | ￥1750.0 |
| 规格： | 100 mg | 产品价格： | ￥2300.0 |
| 规格： | 200 mg | 产品价格： | ￥3950.0 |
| 规格： | 500 mg | 产品价格： | ￥5200.0 |
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MPTP hydrochloride
CAS No. : 23007-85-4
MCE 国际站：MPTP hydrochloride
产品活性：MPTP hydrochloride 是可透过血脑屏障的多巴胺 (dopamine) 神经毒素，能诱导帕金森综合症。MPTP hydrochloride 是 MPP+ 的前体，可以诱导凋亡 (apoptosis) 作用。
研究领域：GPCR/G Protein | Neuronal Signaling | Apoptosis
作用靶点：Dopamine Receptor | Apoptosis
In Vitro: Pretreatment with 50 mM 4-phenylpyridine, reduces IC50 (concentration for 50% inhibition of twitch amplitude) values of MPTP from 53 to 18 mM and d-tubocurarine from 0.7 to 0.3 mM, respectively, in mouse phrenic nerve-diaphragm.
In Vivo: MPTP hydrochloride can be used in animal modeling to build Parkinson's syndrome models.
The toxic effect of MPTP can be completely abolished in vivo by treatment with a monoamine oxidase inhibitor and potentiated by an inhibitor of catechol-O-methyltransferase. Gas1 expressions are significantly elevated in the majority of the reactive astrocytes of the brains with LPS or MPTP insults in animal models.
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