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Telomere Maintenance: ACD, BLM, DCLRE1C, DKC1, ERCC1, ERCC4, HSPA1L, MRE11A, MYC, NBN (NBS1), PARP1 (ADPRT1), PIF1, POT1, PRKDC, PTGES3, RAD50, RFC1, RTEL1, SMG6, TEP1, TERF1, TERF2, TERF2IP, TERT, TINF2, TNKS (TIN1), TNKS2, XRCC5, XRCC6 (G22P1).
Telomere-Associated Complexes: Shelterin: ACD, POT1, RAP1A, TERF1, TERF2, TINF2.
Telomerase: DKC1, GAR1, NHP2, NOP10, TERT, WRAP53.
SLX4: SLX4, ERCC1, ERCC4, EME1, MSH2, MSH3, MUS81, PLK1, TERF2, TERF2IP.
Telomere Regulation: Regulation of Telomere Length: RTEL1, TEP1, TERF1, TERF2IP, TNKS (TIN1).
Shelterin Complex Regulation: DCLRE1B, KRIT1, RASSF1, RAPGEF1, TPP1.
Telomerase Regulation: ABL1, AKT1, ATP5C1, BCL2, EGF, IGF1, KRAS, MEN1, MYC, PAX8, PINX1, PPARG, PPP2R1A, PPP2R1B, PRKCA, PRKCB, RB1, SART1, SMAD3, SP1, SSB, TGFB1, TP53.
Other Genes Associated with Telomeres: ATM, CDK2, CHEK1, CHEK2 (RAD53), HAT1, HNRNPA2B1, HNRNPD, HSP90AA1, NCL, OBFC1, PURA, RAD17, RIF1, SIRT2, SIRT6, TP53BP1, SUN1.
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文献和实验Detection of Telomerase Activity by PCR-Based Assay
Telomeres are distal ends of human chromosomes composed of tandem repeats of the sequence TTAGGG. Possible functions of telomeres include prevention of chromosome degradation, end-to-end fusions, rearrangements, and chromosome loss. Human
Detection of Telomerase hTERT Gene Expression and Its Splice Variants by RT-PCR
The finite growth potential of normal cells is termed “cellular senescence” and its regulation appears to involve specialized DNA structures known as telomeres that exist at the ends of all eukaryotic chromosomes (1 ). Human telomeres
Assessment and Quantification of Telomerase Enzyme Activity
The enzyme telomerase is activated in 80–90% of all human malignancies and immortal cell lines, where it functions to maintain the integrity of chromosomal-end structures called telomeres. Telomerase enzyme activity can be detected
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