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先兆子痫基因表达PCR芯片可以同时检测影响胎盘发育失调的84个关键基因的表达。先兆子痫主要的研究方向集中在明确妇女在怀孕期间是否产生先兆子痫的高风险。此外，研究还涉及明确先兆子痫的关键基因及新的治疗靶点，抑制或逆转的条件。利用实时定量PCR，研究者可以方便并且可信地对先兆子痫相关基因进行同时检测。
Placental Genes Dysregulated During Pre-eclampsia: Early-Onset: ABCG2 (BCRP), ANGPT2, ATP1B1, BCL6, BHLHE40, CFD, COL14A1, CRH, DCN, DUSP1, F5, FABP4, FLT1 (VEGFR1), FSTL3, HGF, HSD17B1, HTRA1, IGF1, INHA, INHBA, LEP, LPL, MMP12, SOD1, SPP1, VCAN.
Late-Onset: ABCC1 (MRP1), ABCG2, APLN, ATP2A2, BCL6, BHLHE40, C3, CAV1, CD40LG (TNFSF5), CDH13, CLU, CP, CRH, CRHBP, CXCL9, CYP26A1, DUSP1 (PTPN16), F5, FLT1, FSTL3, HBEGF (DTR), HP, HSD17B1, HSP90AA1, HTR3A, HTRA1, IFNG, IGFBP3, IL11, IL15, IL1A, INHA, INHBA, ITGB3, KIT (CD117), KRT19, LEP, MAS1, NCAM1, NDRG1, NTRK2, PDGFD, PGR, QPCT, SERPINA3, SOD1, SPP1, STAT1, TAC1, TGFB1, TREM1.
Genes Involved in Pregnancy: Pregnancy Maintenance: ADM, ANGPT2, CRH, CRHBP, DCN, FLT1 (VEGFR1), HIF1A, HLA-G, IL11, KRT19, LEP, PGF, PGR, SOD1, TAC3, TGFB1.
Angiogenesis: ANGPT2, C3, CCL2 (MCP-1), CDH13, CXCL10 (INP10), DCN, ENG (EVI-1), FLT1 (VEGFR1), FLT4 (VEGFR2), HIF1A, IL18, IL1A, IL6, IL8, ITGB3, MMP9, NDRG1, NOS3 (eNOS), PGF, TEK (TIE2), VEGFA.
Vasodilation: ADM, AGTR1, APLN, MAS1, NOS3 (eNOS).
Tissue Remodeling: MMP9, MMP12, PAPPA2, SERPINA3.
Inflammation: AGTR1, BCL6, C3, CCL2 (MCP-1), CD40LG (TNFSF5), CRH, CXCL10 (INP10), CXCL9 (MIG), FABP4, IL10, IL15, IL18, IL1A, IL2, IL6, IL8, SERPINA3, SPP1, TAC1, TGFB1, TNF.
Oxidative Stress: CLU, CYP26A1, DUSP1 (PTPN16), HIF1A, MMP9, SOD1.
Adhesion: CAV1, CD40LG (TNFSF5), CDH13, COL14A1, ENG (EVI-1), FSTL3, ITGB3, NCAM1, SPP1, VCAN.
Cells Involved in Pre-eclampsia: Th1 Cells: CD40LG (TNFSF5), IFNG, IL18, IL2, STAT1, TNF, VEGFA.
Endothelial Cells: ANGPT2, CAV1, CCL2 (MCP-1), CD40LG (TNFSF5), CDH13, EDN1, FLT4 (VEGFR2), HIF1A, ITGB3, NOS3 (eNOS), TEK (TIE2), TGFB1, VEGFA.
Neutrophils: CCL2 (MCP-1), EDN1, IFNG, IL6, IL8, TREM1.
Natural Killer Cells: IL2, IL15, IL18.
Hemostasis & Heme Metabolism: ABCG2 (BCRP), ATP1B1, ATP2A2, C3, CFD, CYP26A1, F5, HP, INHA, INHBA.
Hormones & Growth Factors: ADM, APLN, CRH, CRHBP, EDN1,
HBEGF (DTR), HGF, IGF1, INHA, INHBA, LEP, PDGFD, PGF, QPCT, TAC1, TAC3.
Signal Transduction: Nitric Oxide Signaling: CAV1, EDN1, ENG (EVI-1), HSP90AA1, NOS3 (eNOS).
Insulin Signaling: HTRA1, IGF1, IGFBP3.
Placental Genes Dysregulated During Pre-eclampsia: Early-Onset: ABCG2 (BCRP), ANGPT2, ATP1B1, BCL6, BHLHE40, CFD, COL14A1, CRH, DCN, DUSP1, F5, FABP4, FLT1 (VEGFR1), FSTL3, HGF, HSD17B1, HTRA1, IGF1, INHA, INHBA, LEP, LPL, MMP12, SOD1, SPP1, VCAN.
Late-Onset: ABCC1 (MRP1), ABCG2, APLN, ATP2A2, BCL6, BHLHE40, C3, CAV1, CD40LG (TNFSF5), CDH13, CLU, CP, CRH, CRHBP, CXCL9, CYP26A1, DUSP1 (PTPN16), F5, FLT1, FSTL3, HBEGF (DTR), HP, HSD17B1, HSP90AA1, HTR3A, HTRA1, IFNG, IGFBP3, IL11, IL15, IL1A, INHA, INHBA, ITGB3, KIT (CD117), KRT19, LEP, MAS1, NCAM1, NDRG1, NTRK2, PDGFD, PGR, QPCT, SERPINA3, SOD1, SPP1, STAT1, TAC1, TGFB1, TREM1.
Genes Involved in Pregnancy: Pregnancy Maintenance: ADM, ANGPT2, CRH, CRHBP, DCN, FLT1 (VEGFR1), HIF1A, HLA-G, IL11, KRT19, LEP, PGF, PGR, SOD1, TAC3, TGFB1.
Angiogenesis: ANGPT2, C3, CCL2 (MCP-1), CDH13, CXCL10 (INP10), DCN, ENG (EVI-1), FLT1 (VEGFR1), FLT4 (VEGFR2), HIF1A, IL18, IL1A, IL6, IL8, ITGB3, MMP9, NDRG1, NOS3 (eNOS), PGF, TEK (TIE2), VEGFA.
Vasodilation: ADM, AGTR1, APLN, MAS1, NOS3 (eNOS).
Tissue Remodeling: MMP9, MMP12, PAPPA2, SERPINA3.
Inflammation: AGTR1, BCL6, C3, CCL2 (MCP-1), CD40LG (TNFSF5), CRH, CXCL10 (INP10), CXCL9 (MIG), FABP4, IL10, IL15, IL18, IL1A, IL2, IL6, IL8, SERPINA3, SPP1, TAC1, TGFB1, TNF.
Oxidative Stress: CLU, CYP26A1, DUSP1 (PTPN16), HIF1A, MMP9, SOD1.
Adhesion: CAV1, CD40LG (TNFSF5), CDH13, COL14A1, ENG (EVI-1), FSTL3, ITGB3, NCAM1, SPP1, VCAN.
Cells Involved in Pre-eclampsia: Th1 Cells: CD40LG (TNFSF5), IFNG, IL18, IL2, STAT1, TNF, VEGFA.
Endothelial Cells: ANGPT2, CAV1, CCL2 (MCP-1), CD40LG (TNFSF5), CDH13, EDN1, FLT4 (VEGFR2), HIF1A, ITGB3, NOS3 (eNOS), TEK (TIE2), TGFB1, VEGFA.
Neutrophils: CCL2 (MCP-1), EDN1, IFNG, IL6, IL8, TREM1.
Natural Killer Cells: IL2, IL15, IL18.
Hemostasis & Heme Metabolism: ABCG2 (BCRP), ATP1B1, ATP2A2, C3, CFD, CYP26A1, F5, HP, INHA, INHBA.
Hormones & Growth Factors: ADM, APLN, CRH, CRHBP, EDN1,
HBEGF (DTR), HGF, IGF1, INHA, INHBA, LEP, PDGFD, PGF, QPCT, TAC1, TAC3.
Signal Transduction: Nitric Oxide Signaling: CAV1, EDN1, ENG (EVI-1), HSP90AA1, NOS3 (eNOS).
Insulin Signaling: HTRA1, IGF1, IGFBP3.
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Pre-Eclampsia 先兆子痫基因表达PCR芯片
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