Cancer Drug Resistance PCR Arr

肿瘤耐药基因表达PCR芯片可用于分析与化疗生物学反应有关的84个关键基因的表达。该芯片包含了药物抗性基因（如P-糖蛋白）、I相代谢基因（P450家族）、和II相代谢基因（如各种共价修饰酶），及其他重要的酶编码基因。此外芯片还包含了与肿瘤相关的基因，如DNA修复酶、细胞周期调控因子及其受体、生长因子、激素和转录因子等。利用该芯片研究者即能够利用该芯片简单可靠地同时检测肿瘤耐药和代谢相关基因的表达。
Drug Resistance: ABCB1 (MDR1), ABCC1 (MRP1), ABCC2 (MRP2), ABCC3 (MRP3), ABCC5 (MRP5), ABCG2 (BCRP), BAX, BCL2, BCL2L1 (BCL-X), MVP (LRP), RB1, TOP1, TOP2A, TOP2B, TP53.
Drug Metabolism: ARNT, BLMH, CLPTM1L (CRR9), CYP1A1, CYP1A2, CYP2B6, CYP2C8, CYP2C9, CYP2C19, CYP2D6, CYP2E1, CYP3A4, CYP3A5, DHFR, EPHX1, GSK3A, GSTP1, NAT2, SOD1, SULT1E1 (STE), TPMT, UGCG.
DNA RePAir: APC, ATM, BRCA1, BRCA2, ERCC3, MSH2, XPA, XPC.
Cell Cycle: CCND1, CCNE1, CDK2, CDK4, CDKN1A (p21CIP1/WAF1), CDKN1B (p27KIP1), CDKN2A (p16INK4), CDKN2D (p19INK4D).
Growth Factor Receptors: EGFR (ERBB1), ERBB2 (Her2), ERBB3, ERBB4, FGF2, IGF1R, IGF2R, MET.
Hormone Receptors: AR, ESR1 (ERa), ESR2 (ERß), PPARA, PPARD, PPARG, RARA, RARB, RARG, RXRA, RXRB.
Transcription Factors: AHR, AP1S1, ELK1, FOS, HIF1A, MYC, NFKB1, NFKB2, NFKBIB (TRIP9), NFKBIE, RELB, TNFRSF11A (RANK).