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肾毒性基因表达PCR芯片可用于研究的84个关键基因的表达，这些基因可以作为肾毒性的潜在的分子标志物。该芯片包含已知肾毒性药物引起的差异表达的基因。利用该芯片，研究者可以方便并且可信地对与肾毒性反应相关的基因进行同时检测。
Up-Regulated: Apoptosis: ANGPTL4, ANXA5, BTG2, CD24, CD44, CDKN1A, CLU, GADD45A, GSTP1, HMOX1, NQO1, RTN4, SOCS3, TNFRSF12A.
Cell Cycle: CCND1, CCNG1, CDKN1A, GADD45A, MCM6.
Metal Ion Binding: BMP1, CCS, CP, CTSS, HMOX1, HMOX2, MT1A.
Oxidative Stress: CLU, G6PD, GPX2, GPX8, HMOX1, HMOX2, NQO1.
Prolifeion: ATF3, BTG2, CCND1, CD24, CDKN1A (p21CIP1/WAF1), CLU, CXCL1, CXCL10 (INP10), GLUL, GPNMB, HMOX1, HSP90AA1, TIMP1, UCHL1, VCAM1.
Tissue Remodeling: CST3, FN1, HAVCR1 (KIM-1), SPP1 (Osteopontin), TIMP1.
Transporters: ABCB1 (MDR1), ABCC2 (MRP2).
Xenobiotic Metabolism: CYP2C19, GSTP1.
Extracellular Matrix: ANGPTL4, CCL3 (MIP-1A), CD44, CST3, FGB, LGALS3, MGP, TIMP1.
Cytoskeleton: CCL3, G6PD, SPRR1A, TMSB10, VIM.
Others: A2M, GC, IGFBP1, LCN2 (NGAL), UGT1A1.
Down-Regulated: Apoptosis: BMP4, CAT, GHR, IGFBP3,
SOD2.
Cell Cycle: BMP4, EGF.
Metal Ion Binding: BHMT, IDH1, RGN, SCD, SOD2, SOD3.
Oxidative Stress: CAT, GATM, IDH1, SOD2, SOD3.
Prolifeion: BMP4, EGF, IGFBP3, NOX4, ODC1, SOD2.
Transporters: SLC22A1, SLC22A5, SLC22A6.
Xenobiotic Metabolism: CYP2D6, FMO2, GSTK1.
Extracellular Matrix: BMP4, CYR61, SOD3.
Others: AASS, ALDH1A1, CALB1, G6PC, GAMT, IPMK, KLK1, NPHS2, OAT.
Up-Regulated: Apoptosis: ANGPTL4, ANXA5, BTG2, CD24, CD44, CDKN1A, CLU, GADD45A, GSTP1, HMOX1, NQO1, RTN4, SOCS3, TNFRSF12A.
Cell Cycle: CCND1, CCNG1, CDKN1A, GADD45A, MCM6.
Metal Ion Binding: BMP1, CCS, CP, CTSS, HMOX1, HMOX2, MT1A.
Oxidative Stress: CLU, G6PD, GPX2, GPX8, HMOX1, HMOX2, NQO1.
Prolifeion: ATF3, BTG2, CCND1, CD24, CDKN1A (p21CIP1/WAF1), CLU, CXCL1, CXCL10 (INP10), GLUL, GPNMB, HMOX1, HSP90AA1, TIMP1, UCHL1, VCAM1.
Tissue Remodeling: CST3, FN1, HAVCR1 (KIM-1), SPP1 (Osteopontin), TIMP1.
Transporters: ABCB1 (MDR1), ABCC2 (MRP2).
Xenobiotic Metabolism: CYP2C19, GSTP1.
Extracellular Matrix: ANGPTL4, CCL3 (MIP-1A), CD44, CST3, FGB, LGALS3, MGP, TIMP1.
Cytoskeleton: CCL3, G6PD, SPRR1A, TMSB10, VIM.
Others: A2M, GC, IGFBP1, LCN2 (NGAL), UGT1A1.
Down-Regulated: Apoptosis: BMP4, CAT, GHR, IGFBP3,
SOD2.
Cell Cycle: BMP4, EGF.
Metal Ion Binding: BHMT, IDH1, RGN, SCD, SOD2, SOD3.
Oxidative Stress: CAT, GATM, IDH1, SOD2, SOD3.
Prolifeion: BMP4, EGF, IGFBP3, NOX4, ODC1, SOD2.
Transporters: SLC22A1, SLC22A5, SLC22A6.
Xenobiotic Metabolism: CYP2D6, FMO2, GSTK1.
Extracellular Matrix: BMP4, CYR61, SOD3.
Others: AASS, ALDH1A1, CALB1, G6PC, GAMT, IPMK, KLK1, NPHS2, OAT.
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Nephrotoxicity PCR Array 肾毒性基因表达PCR芯片
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