Fatty Liver PCR Array 脂肪肝基因表达P

脂肪肝基因表达PCR芯片可用于研究与非酒精脂肪肝（NAFLD）和肝胰岛素抗性相关的84个关键基因的表达。芯片中包含了脂肪素和胰岛素信号通路相关肝基因，代谢酶和转运蛋白，通常在NIDDM中异常表达的基因，炎症和细胞凋亡相关的基因等。芯片结果帮助研究者洞察研究肝胰岛素抗性和代谢异常的机制。利用该芯片研究者即能够利用该芯片简单可靠地同时检测NAFLD机制相关的基因表达。
Insulin Signaling Pathway: AKT1, FOXA2 (HNF3B), FOXO1, GSK3B, IGF1, IGFBP1, INSR, IRS1, MAPK1 (ERK2), MAPK8 (JNK1), MTOR, PIK3CA (p110A), PIK3R1 (PI3K p85α), PKLR, PPARGC1A (PGC-1α), PRKAA1, PTPN1, SLC2A4 (GLUT4), SOCS3, SREBF1.
Adipokine Signaling Pathway: ADIPOR1, ADIPOR2, AKT1, CD36, IRS1, LEPR, MAPK8 (JNK1), MTOR, NFKB1, PPARA, PPARGC1A (PGC-1α), PRKAA1, RXRA, SERPINE1 (PAI-1), SLC2A1, SLC2A4 (GLUT4), SOCS3, STAT3, TNF.
Genes Involved in NIDDM: GCK, INSR, IRS1, MAPK1 (ERK2), MAPK8 (JNK1), MTOR, PIK3CA (p110A), PIK3R1 (PI3K p85α), PKLR, PNPLA3, SLC2A2, SLC2A4 (GLUT4),
SOCS3, TNF, XBP1.
Metabolic Pathways: Carbohyde Metabolism: ACLY, G6PC, G6PD, GCK, GSK3B, MLXIPL, PCK2, PDK4, PKLR, RBP4.
Beta-Oxidation: ACADL, ACOX1, AKT1, CPT1A, CPT2, FABP1, IRS1, MTOR, PPARA.
Cholesterol Metabolism/Transport: ABCA1, APOA1, APOB, APOC3, APOE, CD36, CNBP, CYP2E1, CYP7A1, HMGCR, LDLR, LEPR, NR1H2, NR1H3, NR1H4, PPARA, PPARG, PRKAA1, RXRA, SREBF1, SREBF2.
Other Lipid Metabolism/Transport: ACACA, ACSL5, ACSM3, DGAT2, FABP3, FABP5, FASN, GK, HNF4A, LPL, PNPLA3, PPA1, SCD, SLC27A5.
Oxidative Phosphorylation: ATP5C1, NDUFB6, PPA1.
Inflammatory Response: CEBPB, FAS
(TNFRSF6), IFNG, IL10, IL1B, IL6, NFKB1, RXRA, TNF.
Apoptosis: AKT1, CASP3, CEBPB, FAS (TNFRSF6), MAPK1 (ERK2), MAPK8 (JNK1), NFKB1, PIK3CA (p110A), PPARG, PRKAA1, RXRA, SERPINE1 (PAI-1), SOCS3, TNF.