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G-Protein-Coupled Receptors (GPCRs) Bioactive Lipid Receptors: S1PR1, LPAR1, S1PR3, LPAR2, S1PR2.
Metabotropic Glutamate, GABA- B-like Receptors: CASR, GRM1, GRM2, GRM4, GRM5, GRM7.
Rhodopsin-like Receptors: ADORA2A, ADRB1, ADRB2, AGTR1, AGTR2, AGTRAP, DRD1, DRD2, S1PR1, LPAR1, S1PR3, LPAR2, S1PR2, GALR2, LHCGR, OPRD1, OPRK1, PTGDR, RHO, TSHR.
Secretin-like Receptors: ADORA2A, BAI1, CALCR, CALCRL, CRHR1, CRHR2, GCGR, PTH1R, SCTR.
Other G-protein Coupled Receptors: EDN1.
Pathways Related to G-Protein-Coupled Receptor Protein Signaling DoPAmine Receptor Pathway: DRD1, DRD2, OPRD1.
G-protein Signaling, Coupled to cAMP Nucleotide Second Messenger (cAMP / PKA):ADCY5, ADORA2A, ADRB1, ADRB2, CALCR, CALCRL, CCL2, COL1A1, CRHR1, CRHR2, CYP19A1, DRD1, S1PR1, S1PR3, EDN1, GALR2, GCGR, GNAQ, GNAS, GRM2, GRM4, IL1R1, IL1R2, LHCGR, NOS2,
OPRD1, OPRK1, PTGS2, PTH1R, RGS2, TSHR, UCP1, VEGFA.
G-protein Signaling, Coupled to IP3 Second Messenger (PLC): AGTR1, CALCR, CASR, LPAR1, LPAR2, EDN1, GNAQ, GRM5, PIK3CG.
Metabotropic Glutamate Receptor Pathway: GRM1, GRM2, GRM4, GRM5, GRM7.
Neuropeptide Signaling Pathway: BAI1, OPRD1.
Adenosine Receptor Signaling Pathway: ADCY5, ADORA2A.
Calcium Signaing Pathway (PKC, NFAT, etc.): CCL2, CCL4, COL1A1, EGR1, ELK1, ELK4, PTGS2.
PKC Pathway (Ca2+, MEK, etc.): AGTR2, COL1A1, DUSP14, EGR1, FGF2, FOS, IL1R1, IL1R2, JUN, JUNB, MMP9, MYC, NOS2, PRKCA, PTGS2, RGS2, SERPINE1, SOCS1.
Protein Tyrosine Kinase Pathway: ADRB2, AKT1, CCL4, CTGF, PDPK1, PRKCA, RGS2, SOCS1, YWHAZ.
Protein Serine / Threonine Kinase Pathway: AKT1, CDKN1B, PDPK1, PTGDR.
MAPKKK Cascade: ADRB2, AGT, S1PR2, FGF2, GRM1, GRM4, PRKCA, TNF, UCP1.
PI-3 Kinase Pathway: AKT1, BCL2, BCL2L1, CCND1, CDKN1B, CFLAR, PDPK1, PIK3CG, PTGS2.
NO-cGMP Pathway: AGTR2, NOS2, PTGS2, TNF.
Rho Pathway: CDKN1B, CTGF, FOS, IL1B, PTGS2, RHO, SERPINE1.
IκB Kinase / NFκB Cascade: AGT, CFLAR, LPAR1, ICAM1, IL1B, IL2, MAX, NOS2, PTGS2, TNF, VCAM1. JAK-STAT
Cascade: CCL2, CDKN1A, SOCS1.
Other Genes Related to G-Protein-Coupled Receptor Protein Signaling: ARRB1, ARRB2, CCNE1, CCNE2.
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文献和实验Crosstalk Coregulation Mechanisms of G Protein- Coupled Receptors and Receptor Tyrosine Kinases
G protein-coupled receptors (GPCRs) and receptor tyrosine kinases (RTKs) are transmembrane receptors that initiate intracellular signaling cascades in response to a diverse array of ligands. Recent studies have shown that signal transduction
Visualizing G Protein-Coupled Receptor Signalsomes Using Confocal Immunofluorescence Microscopy
The heptahelical G protein-coupled receptors (GPCRs) receive and transmit a wide range of extracellular stimuli and induce a wide array of cellular responses by activating signaling kinases. It has become increasingly evident that the agonist
. Vidi, P.A. and Watts, V.J. 2009. Fluorescent and bioluminescent protein‐fragment complementation assays in the study of G protein‐coupled receptor oligomerization and signaling. Mol. Pharmacol. 75:733‐739
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