Genistin (Genistine), an isoflavone belonging to the phytoestrogen family, is a potent anti-adipogenic and anti-lipogenic agent. Genistin attenuates cellular growth and promotes apoptotic cell death breast cancer cells through modulation of ERalpha signaling pathway[1][2][3].
体外研究 (In Vitro)
Genistin causes negative regulation of ERα. Genistin also effectively down-modulates ER nuclear translocation as well DNA binding activity in breast cancer cells. Moreover, GS effectively induced apoptosis and suppressed levels of oncogenic markers in MCF-7 cells[3].
MCE has not independently confirmed the accuracy of these methods. They are for reference only.