生物活性 NG25 is a potent dual TAK1 and MAP4K2 inhibitor, with IC50s of 149 nM and 21.7 nM, respectively.
体外研究(In Vitro) NG25 is a potent dual TAK1 and MAP4K2 inhibitor, with IC50s of 149 nM and 21.7 nM, respectively. NG25 also potently suppresses several kinases such as LYN, CSK, FER, p38α, ABL,ARG and SRC, with IC50s of 12.9, 56.4, 82.3, 102, 75.2, and 113 nM, respectively[1]. NG25 is very potent suppressor of CpG B- or CpG A-stimulated secretion of IFNα and CL097-stimulated secretion of IFNβ, with complete inhibition by 400 nM[2]. NG25 treatment reduces cell viability of all tested breast cancer cell lines in a dose dependent manner. NG25 (2 μM) enhances the cytotoxic effect of Dox on breast cancer cells[3].
分子量 537.58
性状 Solid
Formula C29H30F3N5O2
CAS 号 1315355-93-1
运输条件 Room temperature in continental US; may vary elsewhere.
储存方式 Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year 溶解性数据 In Vitro: DMSO : 16.67 mg/mL (31.01 mM; ultrasonic and warming and heat to 60°C)
配制储备液 浓度溶剂体积质量 1 mg 5 mg 10 mg 1 mM 1.8602 mL 9.3009 mL 18.6019 mL 5 mM 0.3720 mL 1.8602 mL 3.7204 mL 10 mM 0.1860 mL 0.9301 mL 1.8602 mL * 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 储备液的保存方式和期限:-80℃, 2 years; -20℃, 1 year。-80℃ 储存时,请在 2 年内使用, -20℃ 储存时,请在 1 年 内使用。
In Vivo: 请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂: