Losmapimod (GSK-AHAB) 是一种有效的，具

Losmapimod (GSK-AHAB) is a selective, potent, and orally active p38 MAPK inhibitor with pK_is of 8.1 and 7.6 for p38α and p38β, respectively^[1].

pKi: 8.1 (p38α), 7.6 (p38β)

In the spontaneously hypertensive stroke-prone rat (SHR-SP), chronic treatment with GSK-AHAB significantly and dose-dependently improves survival, endothelial-dependent and -independent vascular relaxation, and indices of renal function, and it attenuates dyslipidemia, hypertension, cardiac remodeling, plasma renin activity (PRA), aldosterone, and interleukin-1β (IL-1β)^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

383.46

Solid

C₂₂H₂₆FN₃O₂

585543-15-3

洛批莫德

Room temperature in continental US; may vary elsewhere.

Ethanol : 33.33 mg/mL (86.92 mM; Need ultrasonic)

DMSO : 27.5 mg/mL (71.72 mM; Need ultrasonic)

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用； 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

• 1.

  请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% saline

  Solubility: 2.75 mg/mL (7.17 mM); Suspended solution; Need ultrasonic

• 2.

  请依序添加每种溶剂： 10% DMSO 90% (20% SBE-β-CD in saline)

  Solubility: 2.75 mg/mL (7.17 mM); Suspended solution; Need ultrasonic

• 3.

  请依序添加每种溶剂： 10% DMSO 90% corn oil

  Solubility: ≥ 2.75 mg/mL (7.17 mM); Clear solution

• 4.

  请依序添加每种溶剂： 10% EtOH 90% (20% SBE-β-CD in saline)

  Solubility: 2.5 mg/mL (6.52 mM); Suspended solution; Need ultrasonic

• 5.

  请依序添加每种溶剂： 10% EtOH 90% corn oil

  Solubility: ≥ 2.5 mg/mL (6.52 mM); Clear solution