Ciluprevir（BILN 2061）是特异的拟肽类 H

Ciluprevir  (Synonyms: BILN 2061; BILN 2061ZW)

Ciluprevir（BILN 2061）是特异的拟肽类 HCV NS3 蛋白酶抑制剂，IC₅₀ 为 3.0 nM。

生物活性    
Ciluprevir(BILN 2061) is a specific and potent peptidomimetic inhibitor of the HCV NS3 protease with an IC50 of 3.0 nM.

分子量    
774.93

Formula    
C40H50N6O8S

CAS 号    
300832-84-2

运输条件    
Room temperature in continental US; may vary elsewhere.

储存方式    
Please store the product under the recommended conditions in the Certificate of Analysis.
 

参考文献

[1]. Llinàs-Brunet M, et al. Structure-activity study on a novel series of macrocyclic inhibitors of the hepatitis C virus NS3 protease leading to the discovery of BILN 2061. J Med Chem. 2004 Mar 25;47(7):1605-8.  [Content Brief] [2]. Thibeault D, et al. Sensitivity of NS3 serine proteases from hepatitis C virus genotypes 2 and 3 to the inhibitor BILN 2061. J Virol. 2004 Jul;78(14):7352-9.  [Content Brief] [3]. Lamarre D, et al. An NS3 protease inhibitor with antiviral effects in humans infected with hepatitis C virus. Nature. 2003 Nov 13;426(6963):186-9.  [Content Brief] [4]. Reiser M, et al. Antiviral efficacy of NS3-serine protease inhibitor BILN-2061 in patients with chronic genotype 2 and 3 hepatitis C. Hepatology. 2005 Apr;41(4):832-5.  [Content Brief]