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- 文献和实验
- 技术资料
- 免疫原:
CD49d (Integrinα4)
- 亚型:
Rat IgG2b
- 形态:
PBS pH 7.2, 0.09% NaN3, 0.2% BSA
- 保存条件:
Store at 4°C and protected from prolonged exposure to light. Do not freeze.
- 克隆性:
Monoclonal Antibody
- 标记物:
PerCP
- 适应物种:
Mouse
- 宿主:
Rat
- 应用范围:
FC
- 浓度:
Concentration:0.2 mg/ml
- 靶点:
Clone number:PS/2
- 抗体英文名:
CD49d (Integrinα4) Antibody-PerCP;流式抗体
- 抗体名:
CD49d (Integrinα4) Antibody-PerCP;流式抗体
- 规格:
25/100 μg
克隆类型 :Rat Monoclonal Antibody;Clone number:PS/2
货 号 :HT1610253
规 格 :25/100 μg ;
亚 型 :
Rat IgG2b
浓 度 :
Concentration:0.2 mg/ml
缓 冲 液 :
PBS pH 7.2, 0.09% NaN3, 0.2% BSA
产品描述 :
CD49d is a 150 kD glycoprotein, also known as α4 integrin or VLA-4 α chain. It is a member of the integrin family, expressed on T and B cells, monocytes, eosinophils, basophils, mast cells, thymocytes, NK cells, and dendritic cells. CD49d is a heterodimer expressed with either of two β chains, β1 (CD29) or β7, to form the VLA-4 (integrin α4β1) or LPAM-1 (integrin α4β7) complexes. CD49d plays a critical role in both adhesion and T cell costimulation. The primary ligands for CD49d are VCAM-1, MAdCAM-1, and fibronectin.
适用物种 :
Mouse
应用范围 :
FC
应用说明 :
The amount of the reagent is suggested to be used ≤ 1.0 µg /10^6 cells in 100 µl
保存条件 :
Store at 4°C and protected from prolonged exposure to light. Do not freeze.
标 记 物 :
PerCP(其他荧光标记请咨询我们)
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文献和实验CD49a/CD49b/CD49c/CD49d/CD49e/CD49f分子
CD49a/CD49b/CD49c/CD49d/CD49e/CD49f 分子 CD49a 常用单克隆抗体或代号: SR84,IB3.1;(VLAa 1) 主要表达细胞: Ta,Ba,M [AS] 分子质量(kDa)和结构: gp210,与CD29组成VLA- 1 功 能: 粘附CA和LM CD49b 常用单克隆抗体或代号: Gi94;(VLA- a 2,ECMR- Ⅱ,Pt- GPIa) 主要表达细胞: Leu,Pt,Fb,En [AS] 分子
ITGA4(CD49D)信号通路、病理作用与靶向治疗药物研究梳理
整合素alpha 4(ITGA4),又称CD49D,是整合素家族的关键亚基。它通过与β1或β7亚基结合,形成功能性异二聚体α4β1(VLA-4)和α4β7,在免疫细胞的黏附、运输及迁移中扮演核心角色。VLA-4还能介导白细胞在活化内皮细胞上的聚集。鉴于ITGA4在多发性硬化、炎症性肠病等多种自身免疫性疾病的病理过程中发挥关键作用,它已成为治疗干预的重要靶点。 ITGA4的表达分布 ITGA4主要分布于巨核细胞、红细胞、干细胞、NK细胞以及T细胞中。在T细胞亚群中,CD49D主要在CD
are not as important, as you are looking for a relatively small number of differences and so can devote more time to the identification of each protein.2D electrophoresis is performed in two steps(1) Isoelectric focusing (IEF) (First dimension electrophoresis): is used
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