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- STI-400
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0.1mg
BKCa抑制剂IbTX
- Cat #: STI-400
- Size: 0.1 mg, 0.5 mg, 1 mg, 5 mg
- Source: Synthetic peptide
- MW: 4230.9 Da.
- Net peptide content: 100%
- Target: KCa1.1 K+ channels
- beriotoxin is a 37 amino acid peptidyl toxin isolated from the scorpion Mesobuthus tamulus and was shown to block large conductance Ca2+ activated K+ channels in smooth muscle cells1. Later it was shown to specifically block KCa1.1 (Slo) channels with Ki of about 1 nM2. In addition, experiments with cloned KCa1.1 channels demonstrate the strong effect of the sloβ subunits on the potency of block by Iberiotoxin3.
Alomone labs is pleased to offer Iberiotoxin (#STI-400), a highly purified synthetic peptide. - Our bioassay
Alomone Labs Iberiotoxin inhibits KCa1.1 channels (mSlo) heterologously expressed in Xenopus oocytes. A. Time course of KCa1.1 channel currents amplitude before (black), during (green, marked by horizontal bar) application of 100 nM Iberiotoxin (#STI-400) for 200 sec and upon wash of the toxin. Currents were elicited every 10 sec by ramp stimulation to +100 mV from a holding of –100 mV for 100 msec. B. Superimposed example current responses before (black) and during (green) application of 100 nM Iberiotoxin (taken from the experiment in A).
Origin
ReferencesMesobuthus tamulus (Eastern Indian scorpion). Purity >98%. Effective concentration 50-100 nM. Sequence ZFTDVDCSVSKECWSVCKDLFGVDRGKCMGKKCRCYQ. Modifications Disulfide bonds between: Cys7-Cys28, Cys13-Cys33, and Cys17-Cys35. Z = Pyrrolidone carboxylic acid. Molecular formula C179H276N50O56S7. CAS number 129203-60-7. 1. Galvez, A. et al. (1990) J. Biol. Chem. 265, 11083. 2. Koschak, A. et al. (1997) Biochemistry 36, 1943. 3. Meera, P. et al. (2000) Proc. Natl. Acad. Sci. U.S.A. 97, 5562.
Publications using this product1. Chen, M. et al. (2016) Physiol. Rep. 4, e12682. 2. Li, Y. et al. (2016) PLoS ONE 11, e0155006. 3. Margas, W. et al. (2016) Phil. Trans. R. Soc. B 371, 20150430. 4. Rabbitt, R.D. et al. (2016) J. Neurophysiol. 116, 825. 5. Webb, T.N. et al. (2016) Am. J. Physiol. 310, F15. 6. Casale, A.E. et al. (2015) J. Neurosci. 35, 15555. 7. Dell’Orco, J.M. et al. (2015) J. Neurosci. 35, 11292. 8. Almog, M. and Korngreen, A. (2014) J. Neurosci. 34, 182. 9. He, S. et al. (2014) J. Neurosci. 34, 5261. 10. Lopez-Gonzalez, I. et al. (2014) Mol. Hum. Reprod. 20, 619. 11. Rowan, M.J. et al. (2014) J. Neurosci. 34, 6611. 12. Brereton, M.F. et al. (2013) PLoS ONE 8, e57451. 13. Chen, M. et al. (2013) Mol. Neurobiol. 48, 794. 14. Gonzalez Corrochano, R. et al. (2013) Br. J. Pharmacol. 169, 449. 15. Qian, Z. et al. (2013) CNS Neurosci. Ther. 19, 954. 16. Tsai, K.L. et al. (2013) Cell. Physiol. Biochem. 31, 938. 17. Weisbrod, D. et al. (2013) Proc. Natl. Acad. Sci. U.S.A. 110, E1685. 18. Zhong, L.R. et al. (2013) PLoS ONE 8, e78727. 19. Hristov, K.L. et al. (2012) Am. J. Physiol. 302, C1632. 20. So, E.C. et al. (2012) Eur. J. Pharmacol. 683, 1. 21. Alle, H. et al. (2011) J. Neurosci. 31, 8001. 22. Wu, S.N. et al. (2011) Cell. Physiol. Biochem. 28, 959. 23. Kita, M. et al. (2010) Am. J. Physiol. 298, R1310. 24. Liu, Y.C. et al. (2008) Eur. J. Pharmacol. 590, 93. 25. Pelucchi, B. et al. (2008) J. Neurosci. Res. 86, 194. 26. Begg, M. et al. (2001) J. Physiol. 531, 95.
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BKCa抑制剂IbTX
¥2000
