华拓细胞库:HBMEC人脑微血管内皮细胞 Human brain microvascular endothelial cells were isolated from brain tissue. Cerebral microvascular endothelial cells are the main components of the blood-brain barrier. They are a single layer of flattened epithelioid cells on the surface of cerebral microvascular lumen, which can restrict soluble substances and cells from entering the brain from the blood. Compared with peripheral endothelial cells, cerebral microvascular endothelial cells have some similar characteristics. The bioactive substances produced and secreted by it play an important role in maintaining vascular tension, regulating blood pressure, anti-thrombosis, etc., and have important pathophysiological significance in the pathogenesis of cerebrovascular diseases. Like peripheral endothelial cells, the surface of cerebral microvascular endothelial cells expresses cell adhesion molecules that regulate the entry of white blood cells into the brain. Its main characteristics are as follows: 1. Cerebral microvascular endothelial cells have many close intercellular connections, which produce high transendothelial impedance and delay the paracellular flux; 2. 2. Cerebral microvascular endothelial cells lack the fenestra structure of endothelial cells, and their liquid phase substances have low pinocytosis levels.
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