- 询价
- Cell Signaling Technology
- 3172
- USA
- 2026年05月28日
- W, IP
- H
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- 询价记录
- 文献和实验
- 技术资料
- 抗体英文名：
Progesterone Receptor (6A1) Mouse mAb
- 抗原：
synthetic peptide corresponding to residues surrounding Ser190 of human progesterone receptor
- 应用范围：
W, IP
- 适应物种：
H
- 保质期：
详见说明书
- 供应商：
CST
- 级别：
详见MSDS文件
- 库存：
大量
- 是否单克隆：
1
- 保存条件：
-20°c
- 规格：
100 ul (10 western blots)/carrier free & custom formulation / quantity
| 规格： | 产品价格： | ￥请询价 | |
|---|---|---|---|
| 规格： | 100 ul (10 western blots) | 产品价格： | ￥请询价 |
| 规格： | carrier free & custom formulation / quantity | 产品价格： | ￥请询价 |
pathway more info application references datasheet PDF MSDS PDF protocols
Applications Key: W=Western Blotting IP=Immunoprecipitation
Reactivity Key: H=Human
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on 100% sequence homology.
| Applications | Reactivity | Sensitivity | MW (kDa) | Isotype |
|---|---|---|---|---|
| W IP | H | Endogenous | 90 (PR-A). 118 (PR-B). | Mouse IgG1 |
| Protocols |
|
|---|---|
| Specificity / Sensitivity | Progesterone Receptor (6A1) Monoclonal Antibody detects endogenous levels of total progesterone receptor. It does not cross-react with other PR family members. |
| Source / Purification | Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ser190 of human progesterone receptor. Western Blotting
Western blot analysis of extracts from T47D cells, untreated or stimulated with 100 nM promegestone (R5020) for 1 hour, using Progesterone Receptor (6A1) Mouse mAb. |
| Background | Human progesterone receptor (PR) is expressed as two forms: the full length PR B and the short form PR A. PR A lacks the first 164 amino acid residues of PR B (1,2). Both PR A and PR B are ligand activated but differ in their relative ability to activate target gene transcription (3,4). The activity of PR is regulated by phosphorylation; at least seven serine residues are phosphorylated in its amino-terminal domain. Three sites (Ser81, Ser102 and Ser162) are unique to full length PR B while other sites (Ser190, Ser294, Ser345 and Ser400) are shared by both isoforms (5). Phosphorylation of PR B at Ser190 (equivalent to Ser26 of PR A) is catalyzed by CDK2 (6). Mutation of Ser190 results in decreased activity of PR (7), suggesting that the phosphorylation of Ser190 may be critical to its biological function.
|
| Application References | Have you published research involving the use of our products? If so we'd love to hear about it. Please let us know ! |
| Companion Products |
For Research Use Only. Not For Use In Diagnostic Procedures. |
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文献和实验Inducible Transgenic Mouse Models
system and the estrogen receptor (ER) ligand-binding domain. Less commonly used systems to control gene expression in transgenic mice take advantage of the ligand-binding domain of the progesterone receptor, and the lac and GAL4 inducible systems. The tetracycline
Estrogen-Deficient Mouse Models in the Study of Brain Injury and Disease
involves five catalyzing enzymes which, in a number of steps, convert pregnenolone to progesterone, progesterone to androgens, and finally, androgens to estrogens (1). The final and rate-limiting step in estrogen biosynthesis is the aromatization
细胞数目及细胞活力，一定范围内信号强度和ATP 含量成正比 Estrogen Receptor alpha Antidiv (YA450) (HY-P80663) www.medchemexpress.cn/antibody/estrogen-receptor-alpha-rabbit-mab.html 可用于乳腺癌组织的免疫组化分析 C-erbB-2/HER2 Antidiv (YA771) (HY-P80658) www.medchemexpress.cn/antibody/erbb-2-1c4
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