- 询价
- Cell Signaling Technology
- 3020
- USA
- 2026年05月28日
- W, IP
- H,M,R
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- 文献和实验
- 技术资料
- 抗体英文名：
Insulin Receptor β (L55B10) Mouse mAb
- 抗原：
recombinant human insulin receptor β carboxy-terminal fragments
- 应用范围：
W, IP
- 级别：
详见MSDS文件
- 适应物种：
H,M,R
- 库存：
大量
- 供应商：
CST
- 保质期：
详见说明书
- 是否单克隆：
1
- 保存条件：
-20°c
- 规格：
100 ul (10 western blots)/carrier free & custom formulation / quantity
| 规格： | 产品价格： | ￥请询价 | |
|---|---|---|---|
| 规格： | 100 ul (10 western blots) | 产品价格： | ￥请询价 |
| 规格： | carrier free & custom formulation / quantity | 产品价格： | ￥请询价 |
pathway more info application references datasheet PDF MSDS PDF protocols
Applications Key: W=Western Blotting IP=Immunoprecipitation
Reactivity Key: H=Human M=Mouse R=Rat
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on 100% sequence homology.
| Applications | Reactivity | Sensitivity | MW (kDa) | Isotype |
|---|---|---|---|---|
| W IP | H M R | Endogenous | 95 | Mouse IgG1 |
| Protocols |
|
|---|---|
| Specificity / Sensitivity | Insulin Receptor beta (L55B10) Mouse mAb detects endogenous levels of total insulin receptor β. |
| Source / Purification | Monoclonal antibody is produced by immunizing animals with recombinant human insulin receptor β carboxy-terminal fragments. Western Blotting
Western blot analysis of cell lysates from CHO and CHO/IR transfected with insulin receptor expression cDNA, using Insulin Receptor β (L55B10) Mouse mAb. |
| Background | Type I insulin-like growth factor receptor (IGF-IR) is a transmembrane receptor tyrosine kinase that is widely expressed in many cell lines and cell types within fetal and postnatal tissues (1-3). Receptor autophosphorylation follows binding of the IGF-I and IGF-II ligands. Three tyrosine residues within the kinase domain (Tyr1131, Tyr1135, and Tyr1136) are the earliest major autophosphorylation sites (4). Phosphorylation of these three tyrosine residues is necessary for kinase activation (5,6). Insulin receptors (IRs) share significant structural and functional similarity with IGF-I receptors, including the presence of an equivalent tyrosine cluster (Tyr1146/1150/1151) within the kinase domain activation loop. Tyrosine autophosphorylation of IRs is one of the earliest cellular responses to insulin stimulation (7). Autophosphorylation begins with phosphorylation at Tyr1146 and either Tyr1150 or Tyr1151, while full kinase activation requires triple tyrosine phosphorylation (8).
|
| Application References | Have you published research involving the use of our products? If so we'd love to hear about it. Please let us know ! |
| Companion Products |
For Research Use Only. Not For Use In Diagnostic Procedures. |
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文献和实验胰岛素受体是一个四聚体，由两个α亚基和两个β亚基通过二硫键连接。两个α亚基位于细胞质膜的外侧，其上有胰岛素的结合位点；两个β亚基是跨膜蛋白，起信号转导作用。无胰岛素结合时，受体的酪氨酸蛋白激酶没有活性。当胰岛素与受体的α亚基结合并改变了β亚基的构型后，酪氨酸蛋白激酶才被激活，激活后可催化两个反应∶①使四聚体复合物中β亚基特异位点的酪氨酸残基磷酸化,这种过程称为自我磷酸化(autophosphorylation)；②将胰岛素受体底物(insulin receptor substrate
Assessment of Insulin Secretion in the Mouse
Insulin is synthesized by the β cells of the pancreatic islets as part of a single 110-amino acid precursor, preproinsulin ( see Fig. 1 ). Processing is initiated by removal of the amino terminal, 24-amino acid signal
Receptor-Mediated Transport of Drugs Across the BBB
receptor-mediated transcytosis or transport (RMT) across the BBB in vivo. Certain peptidomimetic monoclonal antibodies (mAb) for insulin receptor or transferrin receptor can also cross the BBB via RMT on the endogenous receptors. These mAb can act
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