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- 详细信息
- 文献和实验
- 技术资料
- 亚型:
IgG
- 形态:
Liquid
- 保存条件:
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
- 克隆性:
Polyclonal
- 标记物:
Unconjugated
- 适应物种:
Rat
- 保质期:
12 months from the shipping date of the product.
- 抗原来源:
Rat
- 目录编号:
GTX78272
- 级别:
Primary Antibodies
- 库存:
Available
- 供应商:
GeneTex
- 宿主:
Rabbit
- 应用范围:
WB, ICC/IF, IHC
- 浓度:
1 mg/ml (Please refer to the vial label for the specific concentration.)
- 靶点:
Reacts with residues 860-872 [NGREVVDSTTSSL] of the rat mGlurR2/3 protein. Sequence is 100% conserved between mGluR2 and mGluR3. Predicted react to human and mouse.
- 抗体英文名:
mGluR2 + mGluR3 antibody
- 抗体名:
mGluR2 + mGluR3 抗体
- 规格:
100 μg
Western Blot analysis of rat brain showing bands migrating at ~100 kDa and ~190 kDa (which may be a dimer of the smaller band).
mGluR2/3 polyclonal antibody (1:250 dilution) was used on perfusion-fixed tissue from rat spinal cord.
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文献和实验还能结合 PrPC-mGluR5 复合物,激活 Fyn 激酶,使含 NR2B 的 NMDAR 滞留于突触膜,进一步放大钙信号。Fyn 还激活 MAPK 通路 (如 ERK、p38),同样促进 tau 病变[7]。 总之,突触功能障碍,决定了“记忆能不能形成”。 图 5. Aβ 导致神经元活动发生变化[7]。 Section.05 线粒体崩坏与 Wnt 信号中断: 雪上加霜 如果说突触功能障碍决定了“记忆能不能形成”,那么线粒体功能障碍则决定
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