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- 2025年12月05日
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- 详细信息
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
312636-16-1
- 规格：
1 mg/5 mg/10 mg/25 mg/50 mg/100 mg/200 mg
| 规格： | 1 mg | 产品价格： | ￥250.0 |
|---|---|---|---|
| 规格： | 5 mg | 产品价格： | ￥523.0 |
| 规格： | 10 mg | 产品价格： | ￥700.0 |
| 规格： | 25 mg | 产品价格： | ￥1200.0 |
| 规格： | 50 mg | 产品价格： | ￥2100.0 |
| 规格： | 100 mg | 产品价格： | ￥3700.0 |
| 规格： | 200 mg | 产品价格： | ￥5688.0 |
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SKI II
CAS No. : 312636-16-1
MCE 国际站：SKI II
产品活性：SKI II 是一种合成的、口服有效的鞘氨醇激酶 (SK) 抑制剂, 抑制 SK1 和 SK2, IC50值分别为 78 μM 和 45 μM。SKI II 通过诱导溶酶体和/或蛋白酶体降解导致SK1的不可逆抑制。
研究领域：Immunology/Inflammation | Stem Cell/Wnt | Apoptosis
In Vitro: SKI II inhibits cell proliferation by suppressing the Wnt/β-catenin signaling pathway. SKI II promotes the degradation of β-catenin by enhancing Wnt5A.
SKI II (1.25 μM, 48 h) in combination with DDP has a clear synergistic effect in human gastric carcinoma SGC7901/DDP cell line.
In Vivo: Chronic SKI II (50.0 mg/kg, 3-weekly i.p. for 16 weeks) administration leads to permanent reduction of S1P concentrations in plasma in mice.
SKI II (50.0 mg/kg, IP; 100 mg/kg, PO) treatment reduces tumor growth in mice bearing solid tumor model.
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