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ICOS ligand 蛋白|ICOS ligand protein|ICOS ligand(Mouse, His & Fc Tag)

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  • ¥3220
  • Sino Biological已认证
  • 50190-M03H
  • 2025年08月12日
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      100 µg

    小鼠 ICOS ligand蛋白|ICOS ligand protein|ICOS ligand(Mouse, C-human IgG1-Fc & His)(产品说明)
    蛋白名称:ICOS ligand蛋白, ICOS ligand protein
    蛋白构建:A DNA sequence encoding the mouse B7-H2 (NP_056605.1) extracellular domain (Met 1-Lys 279) was fused with the C-terminal polyhistidine-tagged Fc region of human IgG1 at the C-terminus.
    表达宿主:HEK293 Cells
    蛋白纯度:> 95 % as determined by SDS-PAGE
    蛋白活性:Measured by its binding ability in a functional ELISA . Immobilized human ICOS at 1 μg/ml (100 μl/well) can bind biotinylated mouse B7-H2 Fc chimera with a linear range of 0.125-1.0 μg/ml .
    蛋白内毒素:< 1.0 EU per μg of the protein as determined by the LAL method
    预测N端:Glu 47
    蛋白分子量:The secreted recombinant mouse B7-H2/Fc is a disulfide-linked homodimer after removal of the signal peptide. The reduced monomer comprises 481 amino acids with a predicted molecular mass of 54.3 kDa. As a result of glycosylation, it migrates as an approximately 75-85 kDa band in SDS-PAGE under reducing conditions.
    蛋白NP号:NP_056605.1
    蛋白氨基酸序列:Met1-Lys279
    蛋白标签:C-human IgG1-Fc & His
    蛋白保存条件:Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

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    • 配体(ligand)

      同锚定蛋白结合的任何分子都称为配体。在受体介导的内吞中, 与细胞质膜受体蛋白结合, 最后被吞入细胞的即是配体。根据配体的性质以及被细胞内吞后的作用, 将配体分为四大类:Ⅰ.营养物, 如转铁蛋白、低密度脂蛋白(LDL)等; Ⅱ.有害物质, 如某些细菌; Ⅲ.免疫物质, 如免疫球蛋白、抗原等; Ⅳ.信号物质, 如胰岛素等多种肽类激素等。  

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