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文献和实验ELISA-Based Quantification of p105 (c-erbB-2, HER2/neu) in Serum of Ovarian Carcinoma
The most important prognostic parameters for gynecologic malignancies are tumor stage, residual tumor after surgical treatment, histological subtype, and degree of malignancy (1-2). However, these factors present an incomplete picture
Developing Anti-HER2/neu Single-Chain Fv Fragments from Phage Display Libraries
One of the major failures of conventional cancer therapy has been the inability to achieve a sufficient differential in toxicity between normal and neoplastic tissues. Since hybridoma technology was established (1 ), monoclonal antibodies
Gene Amplification of c-erbB-2 Detected by FISH
(4 ) and c-erbB-2 (5 ) located at chromosome band 17q11.2 and encoding a 185,000 Dalton tyrosine kinase (2 ,4 ). Studies conducted on human breast cancers showed 28% to have amplified HER2/neu present (7 ) and it was suggested that amplification or increased
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