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- 详细信息
- 文献和实验
- 技术资料
- 免疫原:
KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human CD 20.
- 亚型:
Rabbit Ig
- 形态:
Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 1% BSA with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.
- 保存条件:
Store at 4°C.
- 克隆性:
多克隆
- 标记物:
见下方详细说明
- 适应物种:
H, M, R
- 保质期:
1-2年
- 抗原来源:
KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human CD 20.
- 目录编号:
252263
- 级别:
超纯
- 库存:
大量
- 供应商:
Abbiotec
- 宿主:
Rabbit
- 应用范围:
IF
- 浓度:
见详细说明信息
- 靶点:
CD20
- 抗体英文名:
CD20 Antibody
- 抗体名:
CD20 Antibody
- 规格:
0.1 mg
CD20 Antibody产品详细介绍:
| 产品名称: | CD20 Antibody |
| 说明书: | 【点击查看详细说明及参考图片】 |
| 货号: | 252263 |
| 规格: | 0.1 mg |
| 产品描述: | CD20 is a 33-37 kDa type-III non-glycosylated phosphoprotein spanning the cell membrane four times therefore called TM4. CD20 antigen is expressed on pre-B cells, resting/activated B cells and corresponding neoplastic B cells, but is absent from plasma cells. CD20 regulates B lymphocyte activation and proliferation. |
| 克隆类型: | Rabbit Polyclonal Antibody, FITC-conjugated Antibody |
| 亚型: | Rabbit Ig |
| 免疫原: | KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human CD 20. |
| 适用物种: | H, M, R |
| 应用范围: | IF |
| 应用说明: | IF: 1:20-1:100; Ex: 490-495 nm, Em: 520-530 nm |
| 别名: | B-lymphocyte antigen CD20; Membrane-spanning 4-domains subfamily A member 1; B0lymphocyte surface antigen B1; Leu-16; Bp35; CD20 antigen; MS4A1; CD20 |
| 形态: | Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 1% BSA with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography. |
| 保存条件: | Store at 4°C. Product is guaranteed 6 months from the date of shipment. |
| 参考文献: |
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文献和实验【摘要】目的探讨嵌合抗CD20抗体Fab’片段的抗肿瘤机制。方法应用MTT法检测Fab’片段对Raji细胞生长的抑制作用,用Annexin V-FITC和PI测定Fab’片段对Raji细胞凋亡的诱导作用,用RT-PCR和Western blot检测Raji细胞中bcl-2表达的变化。结果嵌合抗CD20Fab’片段对Raji细胞具有明显的抑制作用IC50值为24.2 µg/ml,并呈剂量依赖性;嵌合抗CD20Fab’片段能诱导Raji细胞的凋亡,并降低Raji细胞中bcl-2基因及其蛋白的表达
CD20 分子 CD20 常用单克隆抗体或代号: B1,Leu16 主要表达细胞: B,FDC [B] 分子质量(kDa)和结构: p33(非糖基化穿膜磷蛋白) 功 能: Ca2+通道,调节B细胞活化和增殖 CD20 Aka L26 33kd phosphoprotein with 3 hydrophobic regions that traverse the cell
;7:711[6] 杨希峰,沈德诚,金宇光等. HI47,一种人成熟B细胞单克隆抗体制备,鉴定及其生物特性研究。上海免疫学杂志,1990;10(2):65-68[7] McLaughlin P,Grillo-Lopez AJ, Link BK,et al. Rituximab chimeric anti-CD20 monoclonal antibody therapy for relapsed indolent lymphoma:half of patient respond to a four-dose
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