MI-136,1628316-74-4

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MI-136

CAS No. : 1628316-74-4

MCE 国际站：MI-136

产品活性：MI-136 是 menin-MLL (PPI) 蛋白互作的抑制剂，其 IC₅₀ 值为31 nM，K_d 值为23.6 nM。MI-136 可抑制 AR 信号通路，有用于去势抵抗性肿瘤的潜能。

研究领域：Epigenetics  |  Vitamin D Related/Nuclear Receptor  |  Apoptosis

作用靶点：Epigenetic Reader Domain  |  Androgen Receptor  |  Apoptosis

In Vitro: MI-136 (0-20) exhibits IC₅₀values of 5.59 μM, 7.15 μM, 5.37 μM and 19.76 μM in LNCaP, VCaP, 22rv1 and PNT2 cells.

In Vivo: MI-136 exhibits T_1/2 of 3.1 h after po administration.
MI-136 (40 mg/kg, ip) leads to a significant decrease in the growth of castration-resistant VCaP tumors.

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