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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
166095-21-2
- 规格：
10 mM * 1 mL/1 mg/5 mg/10 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥2339.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥1100.0 |
| 规格： | 5 mg | 产品价格： | ￥2600.0 |
| 规格： | 10 mg | 产品价格： | ￥3900.0 |
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BMS-191095
CAS No. : 166095-21-2
MCE 国际站：BMS-191095
产品活性：BMS-191095 是线粒体 ATP 敏感的钾通道 (mitoKATP) 的选择性激活剂。BMS-191095 通过打开线粒体 K(ATP) 通道抑制人血小板的聚集。
研究领域：Membrane Transporter/Ion Channel
作用靶点：Potassium Channel
In Vitro: BMS-191095 (50 μmol/L) induces mitochondrial depolarization of vascular smooth muscle (VSM) cells from SD rats.
BMS-191095 (10-100 μmol/L) dose-dependently induces vasodilation in endothelium denuded cerebral arteries.
BMS-191095 (50 μmol/L) increases the frequency of calcium sparks in VSM cells.
BMS-191095 (0-1500 μM) inhibits human platelet aggregation induced by collagen and thrombin with IC50 values of 63.9 and 104.8 μM, respectively.
In Vivo: BMS-191095 (2.5 or 25 μg; intraventricular infusion, 30 min/60 min/24 hours before the induction of ischemia, once) reduces neuronal damage in rats with transient focal cerebral ischemia.
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文献和实验Lacrimal Experimental Protocol (4/4/94)
3. Place BMS at 4°C and LM at 4°C. If not planning to use gelled substrate, coat at 4 - 8 µg/well in 100 µl of dH2O overnight at 4°C. Day of Experiment: 1. Thaw on ice STI , hyaluronidase , collagenase , DNase , dexamethasone , putrescine
Signal Transduction Inhibitors in Cellular Function
BMS-182878, BMS-184467 (57 –59) Inhibitors of the Raf protein kinases ISIS5132, BAY43-9006 (57 –59
类原料市场的主要推手。 如果描述2012年的他汀类原料市场，以进口洛伐他汀突然大举“入侵”为突出特征，引发过去几年相对平静的市场，再起狼烟。虽然没有烽火连天，但也是硝烟漫漫。而代表新势力的全合成类阿托伐他汀和瑞舒伐他汀则全面出击，呈现强势增长。他汀类药物市场格局现状 降血脂药（降胆固醇药）成为全球第二大治疗药物类别，全年销售额达159亿美元，同期增长21％。他汀类降血脂药是降血脂药的主力军，主要品种有辉瑞的Lipitor（阿托伐他订）、默克的Zocor（辛代地汀）、BMS的Pravachol
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