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- 详细信息
- 文献和实验
- 技术资料
- 抗体名:
p27 Kip1 单克隆抗体(兔源)
- 抗体英文名:
p27 Kip1 Antibody, mAb, Rabbit
- 靶点:
p27 Kip1
- 浓度:
0.5mg/mL(常规浓度,以官方说明书为准)
- 应用范围:
Western Blot、免疫细胞化学 / 免疫荧光 (ICC/IF)、免疫组化 (IHC)、免疫沉淀 (IP)
- 宿主:
兔(Rabbit)
- 适应物种:
人、小鼠、大鼠
- 保质期:
- 20℃可稳定保存 半 年
- 抗原来源:
人 p27 Kip1 来源合成肽
- 级别:
科研级
- 库存:
现货
- 供应商:
上海经科化学科技有限公司
- 标记物:
无(Unconjugated)
- 克隆性:
单克隆(Monoclonal)
- 保存条件:
-20℃,可稳定保存 半 年
- 形态:
液体(Liquid)
- 亚型:
Rabbit IgG
- 免疫原:
人 p27 Kip1 来源合成肽
- 规格:
50μl/100μl
| 规格: | 50μl | 产品价格: | ¥1200.0 |
|---|---|---|---|
| 规格: | 100μl | 产品价格: | ¥2200.0 |
| Specificity | This product is specific to p27 Kip1 |
| Host Species | Rabbit |
| Immunogen | A synthesized peptide derived from human p27 Kip1 |
| Species Reactivity | Human; Rat |
| Conjugate | Unconjugated |
| Form | Liquid |
| Storage Buffer | Supplied in 10mM phosphate buffered saline , pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol. |
| Storage Instructions | Store at -20°C. This product is stable for 1 year upon receipt, when handled and stored as instructed. |
| Purification | Affinity-chromatography |
| Isotype | Rabbit IgG |
| Clonality | Monoclonal |
| Target Background | Important regulator of cell cycle progression. Inhibits the kinase activity of CDK2 bound to cyclin A, but has little inhibitory activity on CDK2 bound to SPDYA.Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. Acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry. |
| Synonyms | CDKN1B; CDN1B; Cyclin-dependent kinase inhibitor 1B; Cyclin-dependent kinase inhibitor p27 KIP1; CDKN4; MEN4; |
p27 Kip1 抗体、p27 细胞周期蛋白依赖性激酶抑制剂 1B 抗体、CDKN1B 抗体、p27Kip1 抗体、兔源 p27 Kip1 抗体、单克隆 p27 Kip1 抗体、抗 p27 Kip1 抗体、细胞周期相关抗体、肿瘤相关抗体、WB 抗体、IHC 抗体、IF 抗体、ELISA 抗体
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文献和实验凋亡、抑制血管增生、抑制转移,并且有提高肿瘤细胞对放疗化疗反应的能力[7]。在复发性和难治性肿瘤中显示了较好的疗效。其杀肿瘤细胞存在剂量依赖性。其阻止细胞周期进展主要是通过增加周期蛋白激酶抑制剂(CDKI)p27kip1蛋白水平而诱导细胞停留在G1期[7]。IMC-C225还能抑制肿瘤组织内部的异常血管增生。具有下调肿瘤表达的多种促血管增生因子,如转移生长因子(TGFα)、血管内皮生长因子(VEGF)、白介素-8(IL-8)和纤维生长因子(FGF)等。临床Ⅱ期试验显示明显优于常规治疗法。临床Ⅲ期试验正在
spreading, we developed a method engaging integrin signaling by use of an immobilized anti-integrin monoclonal antibody (mab) directed against the fibronectin (FN) receptor integrin α5β1. ECV 304 cells were plated onto FN or immobilized mab JBS5 (anti
域的信号蛋白Akt和PDK1(phosphoinositidedependentkinase-1)结合, 促使PDK1磷酸化Akt蛋白的Ser308导致Akt的活化. Akt还能通过PDK2(如整合素连接激酶ILK)对其Thr473的磷酸化而被激活.活化的Akt通过磷酸化作用激活或抑制其下游靶蛋白Bad 、Caspase9、NF-κB、GSK-3、FKHR、 p21Cip1和p27 Kip1等, 进而调节细胞的增殖、分化、凋亡以及迁移等. PI3K-Akt信号通路 的活性被类脂磷酸
技术资料




