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文献和实验放线菌 Streptomyces antibioticus产生的抗肿瘤性抗菌素类,除用于小儿癌的治疗外,在实验上用来抑制依赖于 DNA的 RNA合成。即与模板 DNA中的鸟苷基结合而阻抑基于 RNA聚合酶的转录。
that enhances the separation of specific DNA sequences from main-band DNA. The method is based on the fact that actinomycin D binds preferentially to DNA molecules with a high-GC content. This lowers their density relative to main-band and other satellite DNAs
DNase I Footprinting of Small Molecule Binding Sites on DNA
the patterns of sequence-selective recognition of DNA by the anticancer antibiotic actinomycin D. DNase I is a convenient endonuclease for detecting and locating the position of actinomycin-binding sites within GC-rich sequences.
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